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Koolistin 4.5MIU Injection

Salt Composition: COLISTIMETHATE SODIUM

₹3286.00₹5475.40

Inclusive of all taxes

Categories: Infectious Disease

Conditions: Antibacterials

Product Introduction

Koolistin 4.5MIU Injection contains colistimethate sodium, an antibiotic belonging to the polymyxin group of medications. It is used to treat certain bacterial infections, particularly when other antibiotics are unsuitable. This medicine may be administered as an inhalation to treat chronic chest infections in patients with cystic fibrosis caused by Pseudomonas aeruginosa.

Do not use Koolistin 4.5MIU Injection if you are allergic to colistimethate sodium, colistin, or other polymers in the medication. Inform your doctor if you have kidney problems, myasthenia gravis (weakness in skeletal muscles), porphyria (a group of disorders resulting from over-accumulation of porphyrin, which assists haemoglobin, the protein that carries oxygen in blood), or asthma. Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant during treatment.

Serious allergic reactions can occur even with the first dose in some patients. These may include rapid development of rashes, swelling of the face, tongue, and neck, and difficulty breathing. Seek urgent medical attention if you experience signs of an allergic reaction. Do not discontinue treatment without consulting your doctor. Your doctor will determine the appropriate duration of your treatment.

Uses

To treat certain bacterial infections

How it works

Koolistin 4.5MIU Injection, a polypeptide antibiotic, penetrates and disrupts the bacterial cell membrane of susceptible strains of aerobic gram-negative bacteria. It works by killing bacteria.

How to Use

A doctor or nurse in a hospital or clinic setting will give it to you. Depending on the reason, the drug may be given by fast or slow injection into a vein. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Numbness or tingling Dizziness or loss of balance Changes in blood pressure Slurred speech Vision problems Confusion and mental problems Serious Breathing difficulty Respiratory tract paralysis Diarrhea Kidney damage

Expert Tips

This medicine may cause kidney damage; your doctor will perform routine kidney function test to monitor the safety of this medicine. This medicine may make you feel dizzy or cause numbness and tingling in your hands and feet. Do not drive or operate heavy machines while taking this medicine. Tell your doctor immediately if you have severe, continuous, or bloody diarrhea. Sometimes injection site reactions, including itching, burning, swelling, or a lump under your skin, may occur.

References

  1. Monarch Pharmaceuticals, US Food and Drug Administration, [ Revised on Oct 2006] [ Accessed on 13th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050108s026lbl.pdf
  2. Millmount healthcare LTD., Electronic medicines compendium (emc), [ Revised on May 2022] [ Accessed on 13th June 2023], https://www.medicines.org.uk/emc/files/pil.1094.pdf
  3. Koomanachai P, Tiengrim S, Kiratisin P, Thamlikitkul V. Efficacy and safety of colistin (colistimethate sodium) for therapy of infections caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii in Siriraj Hospital, Bangkok, Thailand. Int J Infect Dis. 2007 Sep;11(5):402-6. doi: 10.1016/j.ijid.2006.09.011. Epub 2007 Feb 8. PMID: 17291803.

Safety Advice

Pregnancy: Consult your doctor Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Koolistin 4.5MIU Injection will only be given to a pregnant woman if it is needed.

Lungs: Consult your doctor It is unknown whether Koolistin 4.5MIU Injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Koolistin 4.5MIU Injection because the medicine passes into the breast milk in small amounts and may harm your baby.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS