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Lorbriqua 100mg Tablet 15's
Salt Composition: LORLATINIB
- Manufacturer: PFIZER LTD
- Pack Size: 15 TABLET(s) IN A BOX
- Dosage Form: TABLET
- Strength: 100MG
- Prescription Required
- Storage: Store Lorbriqua Tablet in the original package at controlled room temperature (20°C to 25°C). Keep it out of reach from children.
₹115782.00₹146250.00
Inclusive of all taxes
Product Introduction
Lorbriqua tablet is a tyrosine kinase inhibitor containing lorlatinib, used to treat metastatic non-small cell lung cancer (NSCLC). NSCLC is the most common type of lung cancer, and the metastatic form indicates the cancer has spread to other parts of the body such as bones, liver, brain, or other organs. During treatment, your doctor may periodically monitor white blood cell counts, platelets, blood sugar, electrolytes, and kidney parameters to prevent serious complications. This medicine has the potential to cause liver damage and may cause decreased fertility in males, which could affect your ability to father a child. Discuss any concerns about fertility with your healthcare provider. Inform your doctor if you have been diagnosed with liver disorders, heart failure, high blood cholesterol levels, or hypertension before starting this treatment. Report to your doctor if you experience hypersensitivity reactions such as itchy skin or rashes while taking this medicine. Avoid drinking grapefruit juice while taking this drug, as it may increase the level of the drug in the blood and cause side effects. This tablet contains lactose as an inactive ingredient, which the body is unable to digest. Lactose is a sugar found in milk and dairy products and can cause symptoms such as bloating and abdominal pain. If you have lactose intolerance, inform your doctor before starting this therapy.
Uses
Metastatic non-small cell lung cancer (NSCLC)
How it works
It works by inhibiting the tyrosine kinases, thus preventing the activation of downstream signalling pathways that are involved in cell proliferation, survival, and differentiation. This leads to the inhibition of cancer cell growth and survival.
How to Use
Your doctor will decide the dose and duration of Lorbriqua Tablet based on your disease condition and other factors. Take the tablet at the same time every day, with or without food. Do not chew, crush, or break the tablet. Swallow the whole tablet with water. If you forget to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Cough, chest pain, or worsening of breathing problems Feeling tired, faint, or losing consciousness Yellowing of the skin and eyes, vomiting, abdominal pain Confusion, memory loss, mood swings, difficulty speaking, seeing, or hearing things that are not real Common Increase in cholesterol levels Swelling in hand or legs Double vision difficulty seeing Pain, numbness, or unusual sensations (burning or pin and needles) in arms and legs, difficulty walking Diarrhoea, constipation Headache Weight gain Joint pain, muscle pain Rash Anaemia Increase in cholesterol levels Swelling in hand or legs Double vision difficulty seeing Pain, numbness, or unusual sensations (burning or pin and needles) in arms and legs, difficulty walking Diarrhoea, constipation Headache Weight gain Joint pain, muscle pain Rash Anaemia
Expert Tips
It is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment. Discuss effective non-hormonal contraceptive methods with your healthcare provider, use them during this treatment, and continue for at least six months after the last dose. It is not known if the Lorbriqua Tablet passes into the breast milk. Hence, breastfeeding during this treatment is not recommended. This medicine may increase your blood sugar levels. Your healthcare provider should do blood tests to check your blood sugar levels before starting and during treatment with this drug. It is important to start or change your medicine to control your blood sugar levels. Report to your doctor right away if you get new or worsening signs and symptoms of high blood sugar, such as feeling thirsty, confused and tired. This tablet might cause breathing difficulty and problems with thinking. Hence, it is advisable to avoid driving or operating machines during this treatment. Before starting this treatment, inform your doctor if you are taking any prescription medicines, over-the-counter medicines, vitamins or herbal supplements.
References
- Pfizer Ltd, [Revised on Mar 2021] [Accessed on 1st April 2023], https://labeling.pfizer.com/ShowLabeling.aspx?id=11140&Section=PPI
- Pfizer Ltd, Electronic medicines compendium (emc), [Revised on March 2021] [Accessed on 1st April 2023], https://www.medicines.org.uk/emc/files/pil.10632.pdf
- Pfizer, US Food and Drug Administration, [Revised on March 2021] [Accessed on 1st April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/210868s004lbl.pdf
- Alice T Shaw et al; First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer; The New England Journal of Medicine; Published on 19/11/2020;[Accessed on 1st April 2023]; https://pubmed.ncbi.nlm.nih.gov/33207094/
- Haidar El Darsa, Omar Abdel-Rahman & Randeep Sangha (2020) Pharmacological and clinical properties of lorlatinib in the treatment of ALK-rearranged advanced non-small cell lung cancer, Expert Opinion on Pharmacotherapy, 21:13, 1547-1554,[Accessed on 1st April 2023], https://doi.org/10.1080/14656566.2020.1774552
- Gafer H, de Waard Q, Compter A, van den Heuvel M. Rapid regression of neurological symptoms in patients with metastasis ALK+ lung cancer who are treated with lorlatinib: a report of two cases. BMJ Case Rep. 2019 Jul 24;12(7):e227299,[Accessed on 1st April 2023], https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663151/pdf/bcr-2018-227299.pdf
Safety Advice
Pregnancy: unsafe Lorbriqua Tablet is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Lungs: Consult your doctor Inform your doctor if you have any lung problems before taking Lorbriqua Tablet. Consult your doctor if you have any lung diseases before starting the treatment.
Breastfeeding: unsafe It is not known if Lorbriqua tablets pass into your breast milk or if it will affect your baby. Please consult your doctor before breastfeeding.
Disclaimer
The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.