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Megpro 160mg Tablet

Salt Composition: MEGESTROL

₹560.00₹700.31

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Megpro 160mg Tablet

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Megpro 160mg Tablet contains Megestrol, a synthetic derivative of the naturally occurring hormone progesterone. It is a progestogen used primarily in the management of hormone-dependent breast cancer in patients whose disease has advanced despite conventional anti-estrogen therapy. Your physician may assess the estrogen receptor (ER) status to determine if the cancer is driven by estrogen before prescribing this medication. Beyond breast cancer, Megpro 160mg Tablet is indicated for the treatment of cachexia (muscle wasting), anorexia (loss of appetite), and unexplained weight loss in patients with cancer or weakened immune systems. The medication helps improve appetite and restore body weight in individuals experiencing severe malnutrition due to chronic conditions. Caution is advised in patients with a history of thrombosis, diabetes, or adrenal insufficiency. Common side effects include weight gain, fluid retention, and fatigue. Use of this medication should occur under the supervision of a healthcare provider, as prolonged use may lead to hormonal imbalances. Contraindications include known hypersensitivity to Megestrol or a history of thromboembolic disorders. Proper monitoring during treatment helps mitigate the risk of adverse effects and ensures optimal therapeutic outcomes.

Uses

Megpro 160mg tablet uses are: Treatment of hormone-dependent breast cancer in advanced or recurrent stages. Management of endometrial cancer in certain cases. Treatment of cachexia (muscle wasting), anorexia (loss of appetite), and unexplained weight loss in patients with acquired immunodeficiency syndrome (AIDS) or cancer. Supportive therapy to improve nutritional status and enhance quality of life in individuals with chronic debilitating conditions.

How it works

Megpro 160mg Tablet works by mimicking the actions of natural progesterone, a hormone involved in regulating the growth of certain tissues. It slows the progression of hormone-sensitive cancers, such as breast and endometrial cancer, by inhibiting the effects of estrogen. This action prevents the cancer cells from multiplying and spreading. In cases of cachexia and anorexia, it enhances appetite and promotes weight gain by affecting the hypothalamus (the part of the brain that controls hunger). Additionally, it alters the metabolism of proteins and fats, which helps restore body mass in patients experiencing severe weight loss due to chronic illness. By addressing both hormonal and metabolic imbalances, this medication plays a critical role in improving patients' overall condition.

How to Use

Megpro 160mg Tablet is taken orally and should be used exactly as prescribed by your doctor. The typical dosage for treating breast or endometrial cancer is 160 mg per day, which may be administered as a single dose or divided into smaller doses based on medical advice. It can be taken with or without food, but taking it at the same time each day ensures consistent absorption. The tablet should be swallowed whole with water, without crushing or breaking it. If a dose is missed, it should be taken as soon as possible unless it is close to the next scheduled dose. Dosage adjustments may be required depending on the patient’s response and medical condition.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious: Swelling of the face, lips, tongue Skin rash Breathing difficulty Blood clot in the lungs Heart problems Common: Weight gain and increased appetite Hot flushes High BP High blood sugar levels Rounded face Constipation Swelling of vein Mood changes Hair loss Diarrhea Tiredness and weakness Impotence Passing wind Frequent urination Nausea, vomiting Fluid accumulation Pain

Expert Tips

Inform the doctor if the patient has any history of kidney, liver, allergic reactions before starting this medication. Kidneys,liver, blood pressure and blood glucose levels should be monitored while taking this medication and avoid taking this medication while planning for pregnancy or during pregnancy as it causes harmful effects on developing babies. This medication should not be stopped without proper advice from the doctor because it can worsen the situation. Inform the doctor immediately if there are any signs of swelling and pain in the limbs, shortness of breath, chest pain, severe headache, or changes in vision.

References

  1. Bausch and Lomb UK Ltd., Electronic Medicines Compendium (EMC), [Revised on Sep 2020] [Accessed on 17th Jul 2021], https://www.medicines.org.uk/emc/files/pil.11135.pdf
  2. alniche Life Sciences Pvt Ltd., [Revised on 2021] [Accessed on 19th Jul 2021], https://www.alniche.com/product/megahenz/
  3. Bines et al., Activity of megestrol acetate in postmenopausal women with advanced breast cancer after nonsteroidal aromatase inhibitor failure: a phase II trial, Annals of Oncology, 2014, 25(4), 831-836, https://www.annalsofoncology.org/action/showPdf?pii=S0923-7534%2819%2936501-9
  4. G.G. Dark, A.R. Abdul Razak, Oncology, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 259-282.

Safety Advice

Pregnancy: unsafe This medicine is unsafe to consume during pregnancy. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant.

Lungs: Consult your doctor Inform your physician before starting this treatment if you have lung diseases.

Breastfeeding: Consult your doctor Consult your physician before taking this tablet if you are a breastfeeding mother.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS