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Nexesa 200mcg Injection

Salt Composition: DARBEPOETIN ALFA

₹5303.00₹10500.00

Inclusive of all taxes

Categories: Nephrology

Conditions: Kidney Disease

Product Introduction

Nexesa 200mcg injection contains the active ingredient Darbepoetin Alfa, an antineoplastic drug belonging to the class of hematopoietic growth factors. It is indicated to treat anemia (lower than normal RBC count) in patients with chronic kidney disease. It is also used to treat anemia caused by chemotherapy in patients with certain types of cancer. Symptoms of anemia include fatigue, weakness, and shortness of breath.

Do not use Nexesa 200mcg injection if you are allergic to Darbepoetin Alfa or any other ingredients in the formulation, or if you have uncontrolled blood pressure.

Inform your doctor if you have high blood pressure, anemia, a history of seizures, epilepsy, liver disease, or allergy to latex or hepatitis C. Inform your doctor if you are pregnant or breastfeeding.

Seek immediate medical advice if you experience severe headache, dizziness, drowsiness, confusion, problems with eyesight, nausea, vomiting, or seizures after receiving Nexesa 200mcg injection.

The most commonly reported side effects are hypertension, shortness of breath, swelling in the legs, and cough.

Uses

To treat anemia in chronic kidney failure To treat anemia caused by chemotherapy

How it works

Nexesa 200mcg injection is an erythropoiesis-stimulating protein produced by recombinant DNA technology. It is closely related to erythropoietin and stimulates erythropoiesis by the same mechanism, and both agents bind to progenitor stem cells stimulating the production/differentiation of red blood cells. It works by causing the bone marrow to make more red blood cells.

How to Use

This injection is to be given under the skin (subcutaneous). Your doctor, nurse, or other healthcare professional will train you on how to inject yourself with this pre-filled pen. Do not try to inject the pre-filled pen if you are not well-trained. Never inject the medicine into your vein. If you need help to inject the medicine, visit the nearby hospital or clinic.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Swelling in the face and body Low blood pressure Abdominal pain Shortness of breath cough Serious Heart problems Severe skin reactions Anemia Seizure attack Lung problems

Expert Tips

Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. A nurse or other health provider will give you this medicine. You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to. Do not shake the vial or syringe. You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, heart disease, heart failure, a blood disorder, cancer, any infection, bleeding, or a history of blood clots, heart attack, stroke, or seizures.

References

  1. Aranesp solution for injection in pre-filled pen (SureClick) - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published March 2022. Accessed May 10, 2023. http://www.medicines.org.uk/emc/product/6958/smpc
  2. Darbepoetin Alfa.; Revised June 2011. Accessed May 10, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103951orig1s5173_103951orig1s5258lbl.pdf
  3. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Hematopoietic agents, 12th edition, 1071 - 1072.
  4. KD Tripathi, Essentials of Medical Pharmacology, Haematinics and Erythropoietin, 7th edition, 2013, 611.

Safety Advice

Pregnancy: Consult your doctor There are no adequate and well-controlled studies on the use of Nexesa 200mcg injection in pregnant women. Inform your physician if you are pregnant, suspecting, or planning for pregnancy during the treatment.

Lungs: Consult your doctor It is unknown whether Nexesa 200mcg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Nexesa 200mcg injection because the medicine passes into the breast milk in small amounts and may harm your baby.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS