Octaplex 500IU Injection

Octaplex 500IU injection is a hemostatic agent belonging to the class of clotting factors. It contains human prothrombin complex, which comprises vitamin K-dependent blood coagulation factors II, VII, IX, and X. The injection is indicated for treatment and prevention of acute major bleeding caused by vitamin K antagonists such as warfarin. It is also used in patients with congenital deficiency of vitamin K-dependent coagulation factors II and X. The medicine is used when a purified specific clotting factor product is not available.

Do not use Octaplex 500IU injection if you are allergic to heparin or any ingredient in the medicine. Inform your physician if you have IgA (immunoglobulin A) deficiency with documented antibodies against IgA. Disclose to your physician if you have a history of cardiac problems, liver disease, or if you are scheduled for surgery before starting treatment. This medicine may increase your risk of thrombosis; notify your physician immediately if you experience signs or symptoms of thrombosis, including limb or abdominal swelling or pain, chest pain, decreased blood pressure, shortness of breath, loss of sensation or motor function, altered consciousness, vision disturbances, speech disturbances, confusion, and fever.

Limited data are available on the use of Octaplex 500IU injection in children and adolescents. The most frequently reported adverse effects are headache, nausea, vomiting, decreased blood pressure, and anaemia. As human prothrombin complex is derived from human blood, it may carry a risk of transmitting infectious agents. Discuss the risks and benefits with your physician prior to receiving this medicine.

Treat and prevent bleeding.

Human prothrombin complex contains vitamin K-dependent coagulation factors II, VII, IX, and X, together known as prothrombin complex and antithrombotic protein C and protein S. The clotting factors in this medicine affect the coagulation cascade at various steps. It also increases plasma levels of the vitamin K-dependent coagulation factors and can temporarily correct the coagulation defect of patients with a deficiency of one or several of these factors.

A doctor or nurse in a hospital or clinic setting will give it to you. Your doctor will decide the dose and for how long you will receive this injection based on the severity of your illness, bleeding area, and general condition. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Decreased blood pressure Nausea Vomiting Muscle and bone pain Headache Serious Bleeding Blood clots Skin hypersensitivity reaction Lung infection

Make sure your doctor knows if you have had a stroke, heart attack, deep vein thrombosis (DVT), or any other heart or blood clot problem in the last 3 months. This medicine may increase your risk of blood clots. Tell your doctor right away if you have a sudden or severe headache, problems with vision or speech, chest pain, trouble breathing or swallowing, swelling or tenderness in your leg, or numbness or weakness. This medicine is made from donated human blood. Some human blood products have transmitted viruses to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor if you are concerned about this risk.