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Opdyta 40mg Injection

Salt Composition: NIVOLUMAB

₹39840.00₹43780.00

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Opdyta 40mg Injection

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Opdyta 40mg Injection contains the active substance Nivolumab. It is indicated for the treatment of cancers of the skin, lungs, kidneys, lymph nodes, bladder, oesophagus, and urinary tract. This medicine is indicated when cancer has recurred following treatment with medicines, surgery, and radiation. It is a medication that assists the immune system in fighting cancer more effectively. It works by targeting and inhibiting specific molecules that suppress or weaken the immune system's ability to recognise and attack cancer cells. By blocking these molecules, it helps enhance the immune response against cancer and may shrink or slow tumour growth. One advantage of this and other immunotherapy drugs is that they can produce long-lasting responses in some patients, even after treatment has stopped. This differs from traditional chemotherapy and radiation therapy, which typically provide only temporary benefits and can have significant side effects. It is contraindicated in patients with severe allergic reaction to the drug or its components. Opdyta Injection is also contraindicated in patients with certain autoimmune disorders, such as lupus or rheumatoid arthritis, because the drug can further stimulate the immune system and worsen these conditions. Additionally, it should be used with caution in patients with a history of organ transplants.

Uses

Opdyta 40 mg uses are to treat: Advanced skin cancer Skin cancer that recurs after surgery Advanced non-small cell lung cancer Advanced kidney cancer Hodgkin’s lymphoma (lymph node disease) Advanced cancer of the head and neck Advanced urinary tract and bladder cancer Advanced esophageal cancer

How it works

The therapeutic effect of Opdyta 40mg Inj is to enhance the body's natural immune response to cancer cells. Cancer cells can often evade the immune system by producing proteins that bind to immune cells and prevent them from recognizing and attacking the cancer cells. It works by blocking the interaction between a protein called programmed death-1 (PD-1), found on the surface of immune cells, and its corresponding ligands. Doing so enables the immune system to recognize and attack cancer cells more effectively, helping to slow down or even stop cancer progression. In some cases, treatment with it can lead to long-lasting remission, even after treatment has ended. This is because the drug can stimulate the immune system to "remember" the cancer cells and continue to attack them even after the drug has been cleared from the body.

How to Use

Opdyta 40mg Injection is a medication a healthcare professional administers, typically in a hospital or clinic setting. The medication is given as an intravenous (IV) injection by healthcare professional. The infusion typically takes several hours. You will be closely monitored during and after the infusion to ensure the medication works effectively and to watch for any side effects. The dosage and frequency of administration will depend on the condition being treated and your circumstances. Your healthcare provider will determine the appropriate dosage and schedule for you.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious: Pneumonitis (inflammation of lung tissue) Colitis (inflammation of the colon) Hepatitis (inflammation of the liver) Hypothyroidism Hyperthyroidism Adrenal insufficiency (a condition in which the adrenal glands do not produce enough hormones). Severe allergic reactions Infusion-related reactions Confusion Seizures Neuropathy Eye disorders (such as uveitis or iritis) Common: Fatigue Nausea Skin rash Itching Loss of appetite Diarrhea Constipation Joint pain Headache

Expert Tips

If you are considering or receiving Opdyta 40mg Injection treatment, it is important to discuss the potential risks and benefits of the treatment with your healthcare provider. It is also important to follow all safety precautions and guidelines provided by your healthcare provider to minimize any potential risks associated with treatment. Be sure to report any new or worsening symptoms to your healthcare provider promptly, as some side effects can be serious and require immediate medical attention. If you are a women of reproductive age, you should use effective contraception during and for at least 5 months after the last dose of it to avoid potential harm to a developing fetus. Remember to take care of yourself and prioritise self-care during treatment. This can include eating a healthy diet, getting enough rest, and seeking support from loved ones or support groups.

References

  1. Harrison's Principles of Internal Medicine. 20th edition, 2018, 929-932
  2. Bristol-Myers Squibb, U.S. Food and Drug Administration, Nivolumab, [ Last updated, 4 April 2023]. [ Accessed on 4 April] https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125554s114lbl.pdf .
  3. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 12th edition, 2011,1655-1660
  4. Takeda UK Ltd, Electronic Medicines Compendium (emc), Opdivo 10 mg/mL concentrate for solution for infusion, [Last updated: 30 October 2020], [Accessed on 4 April 2023], https://www.medicines.org.uk/emc/product/6154/smpc

Safety Advice

Pregnancy: unsafe Opdyta 40mg Injection is unsafe for a developing foetus and is not recommended during pregnancy as it can cause harm to the developing foetus.

Lungs: unsafe Opdyta 40mg Injection should be used cautiously in individuals with lung disease, as the medication can potentially worsen lung function. Your healthcare provider will monitor you closely if you have lung disease and adjust your dosage if necessary. If you have lung disease or a history of respiratory problems, discussing the potential risks and benefits of the injection treatment with your healthcare provider is important. Your healthcare provider may recommend additional monitoring or testing to ensure the medication is not causing any adverse effects on your lungs.

Breastfeeding: Consult your doctor It is unknown whether Opdyta 40mg Injection is excreted in human breast milk, so breastfeeding women should discuss the potential risks and benefits of the medication with their healthcare provider before starting treatment.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS