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Pazolit 200mg Tablet

Salt Composition: PAZOPANIB

₹2790.00₹3281.25

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Pazolit 200mg tablet contains pazopanib, an antineoplastic agent belonging to the tyrosine kinase inhibitor class. It is indicated in adults for treatment of advanced renal cell carcinoma and metastatic disease. It is also indicated for certain soft-tissue sarcomas affecting supportive tissues of the body. The medicine functions by inhibiting protein activity involved in cancer cell growth and dissemination. Do not use Pazolit 200mg tablet if allergic to pazopanib or any other ingredient in this formulation. Before starting treatment, inform your physician of any kidney, heart, lung, or liver disease, bleeding disorders, gastric or bowel problems, and thyroid disorders. This tablet may elevate blood pressure; regular blood pressure monitoring during treatment is necessary. No dose adjustment is required for patients with renal disease. Your doctor will advise discontinuing Pazolit 200mg tablet at least 7 days prior to surgical or dental procedures, as it may impair wound healing. This medicine is not recommended for patients under 18 years of age. This medicine may cause infertility; consult your doctor before initiating therapy. Common adverse effects include diarrhoea, hypertension, hair colour changes, nausea, and vomiting.

Uses

Advanced renal cell carcinoma Advanced soft tissue sarcoma

How it works

Pazolit 200mg tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It is an anticancer medication that belongs to the category of tyrosine kinase inhibitors. It interferes with the growth of blood vessels inside the cancer cells by acting against a protein called Vascular Endothelial Growth Factors (VEGF) to shrink cancer cells, ultimately stopping their growth and multiplication.

How to Use

Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Do not take this medicine with food, as it affects the absorption of this medicine. Take Pazolit 200mg tablet at least two hours after a meal or one hour before a meal.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Hypertension Hair color change Increased glucose levels Decreased weight, decrease in appetite Diarrhea Nausea, vomiting Muscle and joint pain Headache Shortness of breath Tiredness Serious Heart problems Bleeding from the anus, mouth Hypothyroidism Interstitial lung disease Infections

Expert Tips

Do not drink grapefruit juice during the treatment with this medicine, as this may increase the chance of side effects. Male patients with female partners with reproductive potential should use effective contraception during the treatment and at least 2 weeks after the last dose to prevent pregnancy. Take the tablet at about the same time each day. Your doctor will regularly do lab tests to check whether the medicine works for you.

References

  1. Highlights Of Prescribing Information - Pazopanib. [Revised on 2021] [cited 2023 Mar 24]. Available from: https://www.novartis.com/us-en/sites/novartis_us/files/votrient.pdf
  2. Summary Of Product Characteristics - Pazopanib. [revised on 2021] [cited 2023 Mar 24]. Available from: https://www.ema.europa.eu/en/documents/product-information/votrient-epar-product-information_en.pdf
  3. Votrient 400 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. 2021 [cited 2023 Mar 24]. Available from: https://www.medicines.org.uk/emc/product/572/smpc
  4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.

Safety Advice

Pregnancy: unsafe Pazolit 200mg tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for at least 2 weeks after your last dose is necessary.

Lungs: Consult your doctor It is unknown whether Pazolit 200mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Pazolit 200mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS