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Pemeplast 500mg Injection

Salt Composition: PEMETREXED

₹1750.00₹3125.63

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Pemeplast 500mg Injection is an anticancer medicine containing the active ingredient Pemetrexed. It belongs to the medication class known as an antifolate agent. It is used to treat non-small cell lung cancer and malignant pleural mesothelioma (cancers of the lungs and chest). This medicine is given alone or in combination with another anticancer medicine, such as cisplatin. Your doctor may prescribe corticosteroids, folic acid, and vitamin B12 to limit the side effects. Blood tests will be taken before each infusion to determine whether your kidney and liver functions are adequate and whether you have enough blood cells to receive this medicine. Before starting treatment with Pemeplast 500mg Injection, it is very important to tell your physician if you currently or previously had any medical conditions of kidney problems, heart disorders, or fluid accumulation in the lungs. Report to your doctor if you recently had or currently having radiotherapy or any vaccination before taking this medication. Inform your doctor immediately if you are planning to get pregnant or think you may be pregnant. Use effective birth control during the treatment and at least six months after the last dose of Pemeplast 500mg Injection. In men, it is recommended not to father a child during and up to 3 months after the treatment. So it is advised to get suggestions about fertility concerns from your doctor. This medication is not recommended for adolescents and children under 18 years of age.

Uses

Malignant pleural mesothelioma Non-small cell lung carcinoma

How it works

Pemplast 500mg inhibits the mechanism required for cell division and replication by blocking specific enzymes involved in folate metabolism (essential for cell replication) and DNA synthesis, which will prevent the cancer cells from growing and multiplying.

How to Use

Pemplast 500mg injection is administered as an intravenous infusion into the vein. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. Serious Blood infection Severe allergic reaction Breathlessness, intense chest pain or cough with bloody sputum Reduced neutrophil granulocytes (white blood cells) Kidney failure Pharyngitis (a sore throat) Abnormal liver function Common Fatigue Nausea, vomiting, diarrhea Redness, swelling or sores in the mouth Loss of appetite, sensation Reduced hemoglobin level Increased skin pigmentation Watery and inflamed eyes, taste change Fever Muscle weakness Dehydration Constipation Skin rash Hair loss

Expert Tips

Discuss your fertility problem with the doctor since, in men, it is advised not to father a child during and after the 3 months of treatment. So it is advised to get suggestions about fertility concerns. Avoid planning for the pregnancy. If you experience any symptoms mentioned as a side effect, consult your doctor immediately. Notify your doctor immediately if you have undergone any radiotherapy or taken any vaccines and other medications before starting with Pemplast 500mg because it might reduce the effectiveness of this medicine and may cause side effects. Inform your doctor if you have or had any history of heart disease, kidney problems,s or liver problems.

References

  1. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs,7th edition, 2013, 863.
  2. Eagle Pharmaceuticals, US Food and Drug Administration, [ Revised on Feb 2020] [ Accessed on 27 - March - 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209472s000lbl.pdf
  3. Seacross Pharmaceuticals Ltd, Electronic medicines compendium (emc), [ Accessed on 27 - March - 2023], https://www.medicines.org.uk/emc/files/pil.8887.pdf

Safety Advice

Pregnancy: unsafe Do not take Pemplast 500mg if you are pregnant because it may cause harm to the unborn baby. Consult your doctor before starting the treatment.

Lungs: Consult your doctor Consult your doctor if you experience any symptoms like; shortness of breath, blockage, or inflammation in the lining of the lung while taking Pemplast 500mg.

Breastfeeding: unsafe It is unsafe to breastfeed while taking Pemplast 500mg because it can cause toxicity to the baby. If you are breastfeeding a baby, it has to be discontinued. Please consult your physician for more advice.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS