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Pivikto 150mg Tablet

Salt Composition: ALPELISIB

₹34600.00₹37106.00

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Pivikto 150mg Tablet contains the active ingredient Alpelisib and belongs to the class of PI3K (phosphatidylinositol-3-kinase) inhibitors. It is used in combination with other anticancer medications to treat metastatic breast cancer in postmenopausal women or in men whose cancer progressed during or after other treatments. Pivikto is also indicated for certain types of PIK3CA-related overgrowth spectrum (PROS), a genetic condition that causes overgrowth and tissue abnormalities. Patients should follow dosage instructions carefully and take the medicine only as prescribed by their healthcare provider. It is important to store the medication according to storage instructions to maintain its efficacy. Use of this medication requires caution in individuals with kidney or liver impairment, and patients should discuss these conditions with their doctor prior to starting therapy. Monitoring for potential side effects, including hyperglycaemia, is recommended. For women who are pregnant or planning pregnancy, consultation with a physician regarding safety is necessary. While taking this medication, long-term use safety should be evaluated with regular follow-ups.

Uses

Pivikto 150 uses are HER2- negative Breast cancer

How it works

Pivikto 150mg tablet is a kinase inhibitor of phosphatidylinositol-3-kinase (PI3K) with inhibitory activity predominantly against PI3K-alpha. In breast cancer cell cells, PI3K inhibition by this medicine induces an increase in estrogen receptor transcription. These enzymes help cancer cells to grow and multiply. By blocking their action, it can reduce cancer growth and spread and help destroy cancer cells.

How to Use

Your doctor will decide the dose and duration of Pivikto 150mg tablet based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, immediately after food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water. If you cannot swallow the tablet, mix the tablets into a glass of water as per doctor advice.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Pivikto 150 side effects are Common Hair loss Decreased weight Decreased appetite Nausea, vomiting Tiredness Serious Cellulitis Hyperglycemia Diarrhea Hypersensitivity reactions Pneumonitis Dehydration Angioedema

Expert Tips

Your doctor may prescribe medicines to prevent nausea and vomiting before treatment. If you vomit after taking the tablet, take the next dose at the regular scheduled time. Women should use effective birth control during treatment and for 1 week after the last dose. Male patients with female partners should also use effective birth control during treatment and for 1 week after the last dose. Inform your doctor if you have kidney disease, lung disease, breathing problems, or diabetes. Do not breastfeed while on treatment and for 1 week after the last dose. Your doctor may recommend regular blood tests during treatment to monitor for unwanted side effects.

References

  1. Piqray 200 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Revised September 2022. Accessed April 28, 2023. https://www.medicines.org.uk/emc/product/11684/smpc
  2. Piqray - alpelisib; Revised on 2019. Accessed April 28, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212526s000lbl.pdf
  3. Kui-Jin Kim, et al., PI3K-targeting strategy using alpelisib to enhance the antitumor effect of paclitaxel in human gastric cancer, Scientific Reports, Jul 2020, [Accessed April 28, 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378194/

Safety Advice

Pregnancy: unsafe Do not take Pivikto 150mg tablet if you are pregnant because this may harm the unborn baby. Inform your physician if you are pregnant, suspecting pregnancy, or planning to get pregnant during the treatment. Use effective contraception during the treatment and for 1 week after the last dose.

Lungs: Consult your doctor It is unknown whether Pivikto 150mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Pivikto 150mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS