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Prepixa 5mg Tablet

Salt Composition: APIXABAN

₹154.00₹187.50

Inclusive of all taxes

Categories: Cardiology

Conditions: Anticoagulants

Product Introduction

Prepixa 5mg tablet is a direct oral anticoagulant (DOAC) belonging to the class of Factor Xa inhibitors. It contains apixaban as the active ingredient. The tablet is used for prophylaxis of deep vein thrombosis (blood clots in the leg veins), which may progress to pulmonary embolism (clots in the lung blood vessels), in patients who have undergone hip or knee replacement surgery. It also reduces the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.

Some formulations of this tablet contain lactose as an inactive ingredient. In patients with lactose intolerance, lactose cannot be digested properly and may cause symptoms including bloating and abdominal pain. Inform your doctor if you have lactose intolerance before beginning treatment.

This drug is contraindicated in patients with hepatic disease associated with coagulopathy and clinically relevant bleeding risk. It is not recommended in patients with severe hepatic impairment. Inform your doctor if you have a history of bleeding disorders, liver disease, or kidney disease. Disclose all medications, including over-the-counter drugs, supplements, and herbal remedies, as this medicine can interact with other anticoagulant medications.

Use of this tablet increases the risk of spinal or epidural haematoma (blood clot in the spinal canal), particularly if patients undergo spinal procedures or receive spinal anaesthesia. Inform your doctor before any medical procedure, including dental work or surgery, so appropriate precautions can be taken. Clinicians should monitor patients for neurological symptoms such as numbness or tingling in the arms or legs, weakness, or loss of bowel or bladder control. If these symptoms occur, urgent treatment is necessary to prevent further neurological damage.

Do not use this medication if you are pregnant or planning pregnancy. This medicine is not recommended for pregnant women as it may cause fetal harm. A pregnancy test will be conducted before treatment begins. Discuss effective birth control methods with your doctor and use them for at least two weeks after the final dose.

Uses

Prophylaxis of Deep vein thrombosis (DVT) Prevent blood clots

How it works

It is a direct oral anticoagulant (DOAC) that works by inhibiting the activity of factor Xa, which is a protein involved in the blood clotting process. Specifically, this drug binds to the active site of factor Xa and blocks its ability to convert prothrombin to thrombin. Thus, preventing the formation of blood clots.

How to Use

Your doctor will decide the dose and duration of the Prepixa 5mg tablet based on the disease condition. Always take this medicine as prescribed by your doctor. The recommended starting oral dose of apixaban is 2.5 mg twice daily. Take the tablet at the same time every day, with or without food. Do not chew, crush, or break the tablet. Swallow the whole tablet with water. If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Allergic reactions Abnormal liver function Low blood pressure, fainting Bleeding in vagina, stomach, nose, red stools. Allergic reactions like swelling in lips, face, throat. Bleeding in brain Common Skin rash Hair loss Itching Reduced number of platelets

Expert Tips

Prepixa 5mg tablet increases the chances of bruising, so it is important to be careful when using sharp objects or participating in activities that may result in injury. It is necessary to inform your doctor before undergoing any medical procedures, including dental work or surgery so that precautions can be taken. Let your doctor know about any other medications you are taking, including over-the-counter drugs, supplements, or herbal remedies. Maintain a consistent intake of foods that are high in fiber, such as fruits, vegetables, and whole grains, this can help to regulate bowel movements and reduce the possibility of constipation, which can increase the risk of bleeding.

References

  1. Bristol Myers Squibb/Pfizer EEIG; Electronic Medicines Compendium; [Revised:2021] [Accessed on 03/Apr/2023] https://www.medicines.org.uk/emc/files/pil.4756.pdf
  2. Highlights of prescribing information; food and drug administration. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/211964s000lbl.pdf [Accessed on 03/Apr/2023].
  3. Annex I summary of Product Characteristics - European Medicines Agency; Available at: https://www.ema.europa.eu/en/documents/product-information/eliquis-epar-product-information_en.pdf [Accessed on 03/Apr/2023].
  4. Katherine Victoria Hurst, John Matthew O’Callaghan and Ashok Handa; ; Quick reference guide to Apixaban; Published 2017 [Accessed on 03/Apr/2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513886/#__ffn_sectitle
  5. SL Greig; Apixaban: A review in venous thromboembolism; [Published:2016] [Accessed on 03/Apr/2023] https://pubmed.ncbi.nlm.nih.gov/27653758/
  6. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics,Modulation of Cardiovascular Function, 12th edition, 2011, 867.
  7. Bertram.G.Katzung, Basic and Clinical Pharmacology, Drugs Used to Treat Diseases of the Blood, Inflammation, & Gout, 14th edition, 617.

Safety Advice

Pregnancy: unsafe Prepixa 5mg tablet is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.

Lungs: Consult your doctor Inform your doctor if you have any lung problems before taking Prepixa 5mg tablet.

Breastfeeding: Consult your doctor It is not known if Prepixa 5mg tablet passes into your breast milk or if it will affect your baby. Please consult your doctor before breastfeeding.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS