Home › Products › Oncology › Rasby 1.5mg Injection

Rasby 1.5mg Injection

Salt Composition: RASBURICASE

₹6685.00₹10781.72

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Rasby 1.5mg Injection is an antihyperuricemic drug belonging to the category of uricolytic agents, containing the active ingredient Rasburicase. It is indicated for the treatment of acute hyperuricemia in patients receiving chemotherapy. When cancer cells break down, they release large amounts of uric acid into the bloodstream. This can cause hyperuricemia, which may lead to kidney damage and other health complications. This medicine can also be used to prevent or treat hyperuricemia in patients with tumour lysis syndrome, a condition in which a large number of cancer cells die over a short period.

In patients with G6PD deficiency, rasburicase can trigger hemolysis (destruction of red blood cells) by generating reactive oxygen species that damage red blood cells. As a result, Rasby 1.5mg Injection is generally contraindicated in patients with G6PD deficiency. If you are diagnosed with this deficiency, inform your physician before taking this medicine as you will be at higher risk of experiencing severe haemolytic anaemia or methemoglobinemia (an abnormal form of haemoglobin).

Children undergoing chemotherapy for leukaemia, lymphoma, or solid tumour malignancies are at risk of developing hyperuricemia, which can lead to kidney damage, seizures, and other complications. This drug helps treat hyperuricemia by rapidly reducing uric acid levels in the blood. It is important to closely monitor children receiving Rasby 1.5mg Injection for any signs of allergic reactions, hemolysis (breakdown of red blood cells), or other adverse effects.

Inform your healthcare provider if you have kidney disease, liver disease, vision problems, or lung problems. Your healthcare provider will conduct regular blood tests to prevent complications. Avoid consuming alcohol as it may cause dizziness.

Rasby 1.5mg Injection is contraindicated during pregnancy as it causes harm to the unborn fetus. Your healthcare practitioner will conduct a pregnancy test before you start treatment with Rasby 1.5mg Injection. Discuss with your doctor effective birth control methods and utilise them for at least two weeks following the last dose.

Uses

Treat high uric acid levels in chemotherapy

How it works

It works by converting uric acid into allantoin, a more soluble compound that can be easily excreted by the kidneys. This reduces the levels of uric acid in the blood and prevents the development of hyperuricemia.

How to Use

The medicine will be administered to you by a healthcare professional in a hospital setting. Rasburicase is given as an injection into a vein (intravenous infusion) over a period of 30 minutes, once a day for up to 5 days. The dose, route of administration, and frequency will be decided by your doctor based on your disease condition and other factors.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Swelling of face, lips, tongue Wheezing and breathing problems Common Nausea, vomiting Fever Swelling Anxiety Headache Abdominal pain Constipation Diarrhea Low phosphate levels in the blood High levels of liver enzymes in the blood Rashes

Expert Tips

Foods that are high in purines should be avoided, such as red meat, organ meats, and some seafood, which can increase uric acid levels and reduce the effectiveness of Rasby 1.5mg Injection. Avoid driving and operating heavy machinery if you feel tired or weak during this treatment. Certain activities or conditions that can trigger gout attacks, such as fasting, rapid weight loss, and stress, should also be avoided while taking Rasburicase. Dehydration can reduce the effectiveness of the medication and increase the risk of side effects, so it is necessary to drink plenty of fluids, especially water, while taking this medicine. Smoking can cause oxidative stress in the body, which can lead to an increase in uric acid levels. It is advised to avoid smoking or using tobacco products while undergoing treatment with Rasby 1.5mg Injection.

References

  1. Sanofi-aventis groupe, Electronic Medicines Compendium (EMC), [Revised on Jun 2021] [Accessed on 27th March 2023], https://www.medicines.org.uk/emc/files/pil.12870.pdf
  2. Sanofi-aventis U.S. LLC (no date) ELITEK., ELITEK (rasburicase) Powder for solution, for intravenous infusion. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/103946s5083lbl.pdf [Accessed on 27th March 2023].
  3. Sanofi S.p.A, Fasturtec name of the medicinal product qualitative and quantitative, Available at: https://www.sanofi.com.sg/dam/jcr:e21c742b-05a1-4b24-9d3b-a7d4c646b3bb/143%20Fasturtec%20SG%20FAS%200718%20CCDSv6.pdf [Accessed on 27th March 2023].
  4. Ueng, S. (2005) Rasburicase (Elitek): A novel agent for tumor lysis syndrome, Proceedings (Baylor University. Medical Center). U.S. National Library of Medicine. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1200736/ [Accessed on27th March 2023].
  5. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Inflammation, Immunomodulation and Hematopoiesis, pharmacotherapy of gout, 12th edition, 2011, 998.
  6. KD Tripathi, Essentials of Medical Pharmacology, Antirheumatoid and antigout drugs, 7th edition, 2013, 217.

Safety Advice

Pregnancy: unsafe It is unsafe to use during pregnancy whether Rasby 1.5mg Injection can be taken during pregnancy. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.

Lungs: Consult your doctor It is unknown whether Rasby 1.5mg Injection can be used for patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: Consult your doctor It is not known if Rasby 1.5mg Injection passes into your breast milk or if it will affect your baby. Please consult your doctor before breastfeeding.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS