Home › Products › Nephrology › Seegraf 0.5mg Capsule

Seegraf 0.5mg Capsule

Salt Composition: TACROLIMUS

₹176.00₹216.93

Inclusive of all taxes

Categories: Nephrology

Conditions: Transplant

Product Introduction

Seegraf 0.5mg Capsule contains tacrolimus, an immunosuppressant belonging to the class of calcineurin inhibitors. It is used together with other medications to prevent organ transplant rejection in patients receiving liver, kidney, heart, or other transplants. The capsule works by controlling your body's immune response, allowing it to accept the transplanted organ.

Do not take Seegraf 0.5mg Capsule if you are allergic to tacrolimus or any other ingredients in this medicine. Inform your physician if you are allergic to any antibiotic group. Tell your doctor if you have or have had liver or heart disease before starting treatment.

Contact your physician immediately if you develop fever, bruising under the skin (which may appear as red dots), unexplained tiredness, confusion, yellowing of the skin or eyes, reduced urine output, vision loss, or seizures after taking this medicine.

Limit your exposure to sunlight and UV light while taking Seegraf 0.5mg Capsule by wearing appropriate protective clothing and sunscreen with a high sun protection factor, due to the potential risk of malignant skin changes with immunosuppressive therapy.

This medicine may cause diarrhea. Inform your physician if you experience diarrhea for more than a day. Before receiving any vaccinations, consult your doctor.

Uses

Seegraf 0.5mg Capsule is used in the treatment of the following: Prevent organ transplant rejections.

How it works

Seegraf 0.5mg Capsule provides immunosuppression by inhibiting T-lymphocyte activation and proliferation and T-helper-cell-dependent B-cell response. It works by attaching to a protein called FKBP-12 and forms a complex called tacrolimus-FKBP, which inhibits the action of calcineurin phosphatase. This, in turn, inhibits the formation of T cells and suppresses the immune response.

How to Use

Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Always take Seegraf 0.5mg Capsule as prescribed by your doctor. Do not open, break, crush, or chew the capsules. Swallow the capsule whole with a glass of water. Take these capsules on an empty stomach or at least 1 hour before or 2 to 3 hours after the meal.

Side Effects

Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them. Common side effects of Seegraf 0.5mg Capsule include : Constipation Stomach pain Leukopenia (low white blood cell count) Infection Diabetes mellitus Tremor High blood glucose levels Headache Paresthesia (tingling or numbness) Nausea Diarrhea Hypertension Anemia Insomnia Fever Urinary tract infection Serious side effects of Seegraf 0.5mg Capsule include : Pericardial effusion (fluid around the heart) Bronchitis Abnormal kidney function CMV infection (Cytomegalovirus) High blood levels of cholesterol, potassium, and magnesium

Expert Tips

Do not eat grapefruit or drink grapefruit juice while you are using Seegraf 0.5mg Capsule. Do not drink alcohol while you are using this medicine. This medicine may interfere with the vaccine. Ask your healthcare professional before getting a flu shot or other vaccines. You must take this medicine as a long-term treatment to prevent rejection of your transplanted organ. Do not stop taking this medicine without informing your doctor. Your doctor may advise you to take certain tests to monitor the effectiveness and side effects of the therapy. Keep all your appointments regularly.

References

  1. Prograf 0.5mg Hard Capsules - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published December 2022. Accessed May 25, 2023. https://www.medicines.org.uk/emc/product/6720/smpc
  2. Highlights Of Prescribing Information, Prograf ® (Tacrolimus) Capsules PROGRAF ® (Tacrolimus) Injection, (for Intravenous Use).; Revised 2012. Accessed May 25, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
  3. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Immunosuppressants, tolerogens, and immunostimulants, 12th edition, 2011, 1008.
  4. KD Tripathi, Essentials of Medical Pharmacology, Immunosuppressant drugs, 7th edition, 2013, 881.

Safety Advice

Pregnancy: Consult your doctor Based on animal studies, Seegraf 0.5mg Capsule can cause harmful effects on the baby. Inform your physician if you are pregnant, suspecting pregnancy or planning to get pregnant before initiating the treatment.

Lungs: Consult your doctor It is unknown whether Seegraf 0.5mg Capsule can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Do not consume Seegraf 0.5mg Capsule if you are breastfeeding because this medicine is excreted into breast milk and may cause harmful effects on the body.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS