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Shilstine 50mg Injection
Salt Composition: LEUCOVORIN CALCIUM
- Manufacturer: SHILPA MEDICARE LTD
- Pack Size: 1 VIAL(s)
- Dosage Form: INJECTION
- Strength: 50MG
- Prescription Required
- Storage: Store Shilstine 50mg Injection in a refrigerator at 2° to 8°C Keep the injection away from the reach of children and pets. If you forgot your dosing schedule, inform your healthcare professional immediately and reschedule the dosing
₹100.00₹265.00
Inclusive of all taxes
Product Introduction
Shilstine 50mg Injection contains Leucovorin Calcium as its active ingredient, a compound chemically related to folic acid. It belongs to the class of folic acid analogs. This medicine is used to reduce the toxic effects of methotrexate during the treatment of certain cancers and is also indicated for the management of accidental methotrexate overdose or overdose of similar medicines. In addition, it is used in combination with other anticancer drugs to treat colorectal cancer and may also be prescribed to manage folic acid deficiency-related anaemia.
Do not use Shilstine 50mg Injection if you are allergic to leucovorin calcium, calcium folinate, or any of its ingredients. It is also contraindicated in patients with pernicious anaemia or megaloblastic anaemia caused by vitamin B12 deficiency. Before starting treatment, inform your doctor if you have anaemia, kidney disease, heart problems, or liver disorders. Also, let your healthcare provider know if you are taking medicines for seizure disorders, as interactions may occur. Seek immediate medical attention if you experience symptoms of an allergic reaction, such as wheezing, difficulty breathing, skin rash, itching, hives, or swelling of the face, lips, or tongue after receiving this injection.
Uses
Methotrexate overdose and toxicity Prevent the harmful effects of methotrexate or similar medications Colorectal cancer Anemia
How it works
Shilstine 50mg Injection counteracts the therapeutic effects of folic acid antagonists such as methotrexate and similar medications by inhibiting the dihydrofolate reductase enzyme. It treats anemia by supplying the folic acid needed for red blood cell formation. It treats colorectal cancer by enhancing the therapeutic effects of another anticancer medication called 5-fluorouracil.
How to Use
A trained physician or nurse in cancer chemotherapy will administer the drug to you. Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. The medicine is administered either intravenously (into your vein) or intramuscularly (into your muscle) based on your disease condition.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Diarrhea Nausea Vomiting Inflammmed and sore mouth Tiredness Serious Allergic reactions
Expert Tips
If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking these medicinal products. Inform your doctor if you have vomited immediately after receiving the injection. If you accidentally take too much Shilstine 50mg Injection. contact your doctor and seek medical advice immediately. Do not stop taking this medicine unless your doctor tells you to. Your doctor will regularly do lab tests to check the effectiveness of the medicine.
References
- Calcium Folinate 10 mg/ml Injection - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. 2020 [cited 2023 Apr 4]. Available from: https://www.medicines.org.uk/emc/product/1572/smpc
- HIGHLIGHTS OF PRESCRIBING INFORMATION [Internet]. [cited 2023 Apr 4]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020140s024lbl.pdf
- Goodman & Gilmanâs, The Pharmacological Basis of Therapeutics, Drug toxicity and poisoning, 12th edition, 2011, 86.
- KD Tripathi, Essentials of Medical Pharmacology, Haematinics and erythropoietin, 7th edition, 2013, 611.
Safety Advice
Pregnancy: Consult your doctor There is a limited number of studies on the safety of Shilstine 50mg Injection during pregnancy, and it is unknown whether the medicine can be given during pregnancy. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.
Lungs: Consult your doctor It is unknown whether Shilstine 50mg Injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Breastfeeding: Consult your doctor Limited information is available on Shilstine 50mg Injection safety during breastfeeding. Inform your physician if you are planning to breastfeed.
Disclaimer
The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.