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Sofocure 400mg Tablet

Salt Composition: SOFOSBUVIR

₹7032.00₹21775.31

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Sofocure 400mg Tablet

Categories: Infectious Disease

Conditions: Hepatitis

Product Introduction

Sofocure 400mg Tablet contains sofosbuvir and velpatasvir as active components. It is indicated for the treatment of chronic hepatitis C, a liver infection caused by the hepatitis C virus (HCV). Treatment duration is often shorter than older treatment regimens. The duration may vary depending on factors including HCV genotype, previous treatment history, and presence of liver cirrhosis. Successful treatment with Sofocure 400mg Tablet can significantly reduce liver inflammation and fibrosis caused by HCV infection. Achievement of viral eradication can substantially reduce the risk of developing liver cirrhosis, liver failure, and hepatocellular carcinoma (a type of liver cancer). Sofocure 400mg Tablet should not be taken if there is a known allergy or hypersensitivity to sofosbuvir, velpatasvir, or any components of the medication. The safety and efficacy of sofosbuvir and velpatasvir combination therapy have not been established in children under 18 years. Use in the paediatric population is currently limited. Alternative treatment options or dosage adjustment is recommended in these cases.

Uses

To treat chronic hepatitis C (HCV) infection.

How it works

Sofosbuvir is a direct-acting antiviral drug (DAA) that inhibits the replication of the HCV virus by targeting a specific protein necessary for viral replication. Velpatasvir is also a DAA that works by blocking the action of another protein involved in the HCV replication process.

How to Use

Read the instructions carefully before taking Sofocure 400mg Tablet. Take them as directed by your doctor. Take it with or without food. This will help to improve absorption. If you experience side effects, stop taking them and talk to your doctor.

Side Effects

Sofocure 400mg Tablet cause some side effects like all medications, although not everyone will experience them. Serious: Hepatitis B reactivation Severe allergic reactions Common: Headache Fatigue Nausea Insomnia Diarrhea Itching (pruritus) Decreased appetite Muscle or joint pain Rash Dizziness

Expert Tips

Before initiating treatment, individuals should be screened for hepatitis B virus (HBV) infection due to the risk of HBV reactivation. Close monitoring of liver function and HBV DNA levels is necessary during and after treatment, particularly for those with a current or prior HBV infection. Additionally, potential drug interactions with other medications should be carefully evaluated, and healthcare providers should be informed about all current medications. Individuals taking amiodarone should be closely monitored for severe bradycardia (decreased heart rate) when co-administered with this medication. Dose adjustments are necessary for patients with severe renal impairment or end-stage renal disease. Assessing the potential impact on psychiatric health, especially in individuals with a history of psychiatric disorders, is necessary. Pregnancy and breastfeeding considerations should be discussed with a healthcare provider, and caution is advised for specific populations such as those with HIV/HCV co-infection and liver transplant recipients.

References

  1. Gilead Sciences Ltd, Electronic medicines compendium (EMC), [Revised on Jan 2021] [ Accessed on 24th June 2023], https://www.medicines.org.uk/emc/files/pil.7294.pdf
  2. Gilead Sciences Inc, US Food and Drug Administration, [Revised on Aug 2017] [Accessed on 24th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208341s007lbl.pdf
  3. Sarah L Greig; Sofosbuvir/Velpatasvir: A Review in Chronic Hepatitis C; Drugs; [Published on 24th June 2023]; [Accessed on 24th June 2023]; https://pubmed.ncbi.nlm.nih.gov/27730529/

Safety Advice

Pregnancy: Consult your doctor There is limited information about the safety of Sofocure 400mg Tablet in pregnancy. If you are pregnant and considering taking them, talk to your doctor about the risks and benefits. They can help you decide if they are right for you.

Lungs: Consult your doctor If you have a chronic lung disease and are considering taking Sofocure 400mg Tablet, talk to your doctor about the risks and benefits.

Breastfeeding: Consult your doctor There is limited information about the safety of Sofocure 400mg Tablet in breastfeeding. If you are pregnant or planning to become one, talk to your doctor about the risks and benefits. They can help you decide if they are right for you.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS