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Sorafenat 200mg Tablet 60's

Salt Composition: SORAFENIB

₹2475.00₹4440.00

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Sorafenat 200mg Tablet is an anticancer medicine containing the active ingredient Sorafenib. It is indicated for advanced renal cell carcinoma (kidney cancer), advanced hepatocellular carcinoma (liver cancer) in patients ineligible for surgery, and differentiated thyroid carcinoma (thyroid cancer) in patients who do not respond to radioactive iodine therapy.

Common side effects include diarrhoea, tiredness, stomach pain, nausea, weakness, rashes, flu-like illness, appetite loss, weight loss, and low blood calcium levels. Inform your doctor if any of these side effects occur or persist.

Before starting treatment with this tablet, inform your doctor if you have heart problems, chest pain, bleeding problems, high blood pressure, or have undergone or are about to undergo surgery. Also inform your doctor if you are allergic to this tablet or any of its ingredients.

Women must use effective contraception during therapy and for 6 months after the last dose. Men must use effective contraception during therapy and for 3 months after the last dose.

Uses

Advanced renal cell carcinoma Advanced hepatocellular carcinoma that cannot be surgically treated Advanced papillary and follicular Hurtle cell thyroid carcinoma

How it works

Sorafenib in Sorafenat 200mg Tablet works by inhibiting multiple receptor tyrosine kinases (enzymes), primarily vascular endothelial growth factor receptors and platelet-derived growth factor-β receptors. This prevents the development of blood vessels in tumour cells (angiogenesis) and arrests the growth and spread of the tumour cells to other organs.

How to Use

Take the Sorafenat 200mg tablet without food (1 hour before or 2 hours after a meal). Swallow with a glass of water. Do not break, crush or chew the tablets.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious: Stevens Johnsons Syndrome and toxic epidermal necrosis Decreased blood flow to the heart Increased risk of bleeding (blood in urine, stool, vomit, cough, etc.) High BP Skin problems Liver problems Problems in wound healing Common: Nausea, stomach pain, diarrhea Tiredness and weakness Infection Hair thinning and patchy hair loss Rash Weight loss Loss of appetite Low levels of calcium in the blood Flu-like illness

Expert Tips

It is advised to seek immediate medical attention if you have swelling in your lower legs, fast heartbeats, or trouble breathing. It may be a sign of heart problems. It may result in bleeding hence inform your doctor if you see blood in stools or urine.

References

  1. Bayer (Pty) Ltd, [Revised on 22nd Apr 2016] [Accessed on 22 Nov 2022], https://www.bayer.com/sites/default/files/NEXAVAR_200_EN_PI.pdf
  2. Bayer HealthCare Pharmaceuticals Inc., US Food & Drug Administration, [Revised on Dec 2018] [Accessed on 22 Nov 2022]], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021923s020lbl.pdf
  3. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
  4. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.

Safety Advice

Pregnancy: unsafe It is unsafe to use Sorafenat 200mg Tablet during pregnancy as it may harm the unborn baby. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. Your physician will conduct a pregnancy test before prescribing this medicine.

Lungs: Consult your doctor Sorafenat 200mg tablet should be cautiously administered in patients with certain lung problems. Consult your doctor if you have any lung disorders.

Breastfeeding: unsafe Do not breastfeed during treatment with Sorafenat 200mg Tablet and for two weeks after the last dose. It is vital to let your physician know if you are breastfeeding or planning to breastfeed before starting treatment with this drug.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS