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Stpase 1.5MIU Injection

Salt Composition: STREPTOKINASE

₹1400.00₹1971.09

Inclusive of all taxes

Stpase 1.5MIU Injection

Categories: Cardiology

Conditions: Heart Disorder

Product Introduction

Streptokinase 1.5MIU injection is an active thrombolytic agent used in the treatment of blood clot-related conditions. It is indicated for deep vein thrombosis, wherein blood clots form in the deep veins, typically in the legs. The injection treats pulmonary embolism, which occurs when a blood clot travels to the lungs and obstructs blood flow. In certain cases, it is used to treat arterial blood clots, such as those responsible for ischaemic strokes. Streptokinase 1.5MIU injection is also used to maintain patency of dialysis fistulas or grafts, which are artificial connections between an artery and a vein utilised in patients with kidney failure requiring dialysis.

Patients with known hypersensitivity or allergic reaction to Streptokinase injection or any components of the medication should not use Streptokinase 1.5MIU injection. It is contraindicated in the presence of active internal bleeding, such as gastrointestinal bleeding or recent surgery. Patients with a history of haemorrhagic stroke should not receive this medication. It is not recommended for patients with severe kidney dysfunction. Elderly patients should always consult a healthcare provider due to higher risk of bleeding associated with age-related changes in blood vessels and other medical conditions. Streptokinase 1.5MIU injection is generally not recommended for use in children because of limited safety and efficacy data in paediatric populations.

Uses

Stpase injection uses are to treat the following: Myocardial Infarction (heart attack) Deep vein thrombosis (DVT) Pulmonary embolism Arterial clots Peripheral arterial disease Thrombosis in dialysis fistulas/grafts

How it works

Stpase 1.5MIU injection operates as a thrombolytic agent by interacting with plasminogen, a precursor protein in the blood. Through its binding, It triggers plasminogen's conversion into plasmin, an active enzyme that dismantles fibrin, the structural framework of blood clots, leading to their dissolution. Promoting this clot breakdown restores blood flow by eliminating blockages in blood vessels, which is essential for preventing tissue damage and related complications.

How to Use

Stpase 1.5MIU injection is administered through the intravenous (IV) route or intracoronory. It may also be delivered through an arterial catheter for more localized treatment. Healthcare professionals perform administration following prescribed dosages and guidelines.

Side Effects

Stpase 1.5MIU injection causes some side effects like all medications, although not everyone will experience them. Stpase inj side effects are: Serious Bleeding Allergic Reactions Hypotension (Low Blood Pressure) Fever and Chills Common Bleeding at Injection Site Nausea and Vomiting Fever Allergic Skin Reactions Minor Drop in Blood Pressure Flushing

Expert Tips

Monitor for signs of allergic reactions, including rash, itching, swelling, and difficulty breathing. Discontinue Stpase 1.5MIU injection and seek medical attention immediately if any allergic symptoms occur. Use with caution in individuals with a history of bleeding disorders, recent surgery, ulcers, or other conditions that might increase bleeding risk. Monitor blood pressure during administration and address any hypotensive episodes. Follow the prescribed dosage as directed by your healthcare provider. Individuals with severe liver or kidney impairment should talk to healthcare providers to assess their condition and determine the appropriate course of action. Use this medication with caution in individuals who have recently undergone surgery, or had significant trauma.

References

  1. KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting Coagulation, bleeding, and thrombosis, 7th edition, 2013, 626.
  2. Tetris Pharma Ltd, Electronic medicines compendium (emc), [Revised on 18th Dec 2021] [ Accessed on 25th 2023], https://www.medicines.org.uk/emc/product/13114/smpc#gref
  3. Adinarayana Kunamneni, Thaer Taleb Abed Abdelghani, Poluri Ellaiah; streptokinase--the drug of choice for thrombolytic therapy; Journal of Thrombosis and Thrombolysis; Published on Feb 2007; Accessed on 25/08/2023; https://pubmed.ncbi.nlm.nih.gov/17111203/

Safety Advice

Pregnancy: unsafe Stpase 1.5MIU injection is unsafe during pregnancy due to potential risks to the developing fetus.

Lungs: Consult your doctor If you have preexisting lung conditions, informing your healthcare provider before starting Stpase 1.5MIU injection is advisable.

Breastfeeding: unsafe It is unknown whether Stpase 1.5MIU injection is excreted in human milk. Always consult a healthcare provider before taking this medication.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS