Home › Products › Cardiology › Sybrava 284mg Injection

Sybrava 284mg Injection

Salt Composition: INCLISIRAN

₹90396.00₹111600.00

Inclusive of all taxes

Categories: Cardiology

Conditions: Diabetes Mellitus

Product Introduction

Sybrava 284 mg Injection contains Inclisiran, a proprotein convertase subtilisin kexin type-9 (PCSK-9) inhibitor belonging to the class of small interfering RNA (siRNA) therapies. It is used to lower low-density lipoprotein cholesterol levels in patients with primary hypercholesterolaemia. The medication is prescribed as an adjunct to statin therapy and dietary management.

Do not use Sybrava 284 mg Injection if you are allergic to Inclisiran or any component of the injection. Use is not recommended during pregnancy and breastfeeding. The medication is not recommended for children and adolescents under 18 years of age.

Before starting treatment, patients should be receiving statin therapy and following a cholesterol-lowering diet. Statin therapy and dietary management must be continued throughout Sybrava 284 mg treatment. Do not discontinue this medicine without consulting your doctor.

Inform your doctor if you have any of the following conditions: kidney disorders, breathing problems, liver disorders, heart problems, or sugar intolerance. Provide your doctor or pharmacist with a complete list of all medications you are currently taking, have recently taken, or plan to take, including over-the-counter medicines and herbal products.

Uses

Sybrava injection uses are as following: Combination to other statin therapy and diet for treating primary hyperlipidemia [heterozygous familial hypercholesterolemia]

How it works

Sybrava 284 mg Injection is a small interfering RNA (siRNA) molecule that interferes with the production of PCSK9 protein in the liver. By inhibiting PCSK9 synthesis, Sybrava 284 mg Injection increases the number of LDL receptors on liver cells, promoting the clearance of LDL cholesterol from the blood. This mechanism ultimately leads to lower LDL cholesterol levels in the bloodstream, helping to reduce the risk of cardiovascular events such as heart attack and stroke.

How to Use

Sybrava 284 mg Injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered as a subcutaneous injection into the abdomen, upper arm, or thigh. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors. The second dose is given after 3 months and the subsequent dose every 6 months.

Side Effects

Like all medications, Sybrava 284 mg Injection can cause side effects, although not everyone who takes it will experience them. Sybrava injection side effects are: Common: Injection site reactions like redness, rash and pain Arthralgia Bronchitis Fever Chills Headache

Expert Tips

It is advised to adopt heart-healthy lifestyle practices, such as eating a balanced diet low in saturated and trans fats, exercising frequently, keeping a healthy weight, and quitting smoking, in addition to taking Sybrava 284 mg Injection. It is advised not to stop your regular statin medications and follow proper diet since Sybrava 284 mg Injection is only effective along with these two therapies. It is not recommended to discontinue the drug without the advice of a healthcare professional even if your symptoms improve. Follow your doctor's advice and routinely check your cholesterol levels. This facilitates monitoring Sybrava 284 mg Injection's efficacy and enables prompt modification of your treatment regimen, if necessary. If a dose is missed for more than three months, a new dosing regimen needs to be initiated.

References

  1. Novartis Pharmaceuticals Corporation , US Food and Drug Administration, [ Revised on July 2023] [ Accessed on 05-03-2024 ], https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/214012s009lbl.pdf
  2. Novartis Pharmaceuticals UK Ltd. Electronic medicines compendium (emc), [ Revised on November 2022] [ Accessed on 05-03-2024], https://www.medicines.org.uk/emc/files/pil.12039.pdf
  3. Leqvio, Novartis Pharmaceuticals Ltd, https://www.leqvio.com/

Safety Advice

Pregnancy: unsafe It is recommended to avoid this medication during pregnancy as Sybrava 284 mg Injection is unsafe during pregnancy as it can cause fetal harm. It is advised to inform your physician if you are pregnant or think you may be pregnant before starting the treatment.

Lungs: Consult your doctor It is unknown whether Sybrava 284 mg Injection Injection is safe for patients with lung problems. Consult your doctor if you have lung disease before starting the treatment.

Breastfeeding: Consult your doctor It is unknown whether Sybrava 284mg Injection is excreted in human milk. It is advised to consult your doctor before taking Sybrava 284 mg Injection. Your doctor may prescribe this if the benefits of the drug outweighs the risks involved.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS