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Tacrotor 0.1% Ointment 10gm

Salt Composition: TACROLIMUS

₹590.00₹692.81

Inclusive of all taxes

Tacrotor 0.1% Ointment 10gm

Categories: Nephrology

Conditions: Transplant

Product Introduction

Tacrotor 0.1% Ointment 10 gm contains the active substance Tacrolimus. It is an immunosuppressant that belongs to the class of medications called calcineurin inhibitors. This ointment is used along with other medicines to prevent organ transplant rejection in patients receiving liver, kidney, heart, or other transplants. It is also indicated to control your body's immune response, enabling it to accept the transplanted organ. Do not use this ointment if you are allergic to tacrolimus or any of the other ingredients of this medicine. Report your doctor if you are allergic to any antibiotic group. Inform your doctor if you have had a liver or heart disease before initiating the treatment. Notify your doctor immediately if you develop fever, bruising under the skin (which may appear as red dots), unexplained tiredness, confusion, yellowing of the skin or eyes, reduced urine output, vision loss, and seizures after taking this medicine. Limit exposure to sunlight and UV light while using tacrolimus by wearing appropriate protective clothing and sunscreen with a high sun protection factor. This is because of the potential risk of malignant skin changes with immunosuppressive therapy. This medicine may cause diarrhoea; inform your doctor if you have diarrhoea for over a day. If you need to receive any vaccinations, consult your doctor before accepting them.

Uses

Tacrotor 0.1 ointment uses: Prevent organ transplant rejections.

How it works

Tacrotor 0.1 Ointment 10gm provides immunosuppression by inhibiting T-lymphocyte activation and proliferation and T-helper-cell-dependent B-cell response. It works by attaching to a protein called FKBP-12 and forms a complex called tacrolimus-FKBP, which inhibits the action of calcineurin phosphatase. This, in turn, inhibits the formation of T cells and suppresses the immune response.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Swelling in the arm or leg Hair loss Itchy skin Constipation, diarrhoea Nausea, vomiting Anemia Headache Cough Serious Increased or decreased heartbeats GI bleeding Liver Injury Seizure Acute kidney failure Lung infection or respiratory problems

Expert Tips

Do not eat grapefruit or drink grapefruit juice while Tacrotor ointment use. Do not drink alcohol while you are using this medicine. This medicine may interfere with the vaccine. Ask your healthcare professional before getting a flu shot or other vaccines. You must take this medicine as a long-term treatment to prevent rejection of your transplanted organ. Do not stop taking this medicine without informing your doctor. Your doctor may advise you to take certain tests to monitor the effectiveness and side effects of the therapy. Keep all your appointments regularly.

References

  1. Prograf 0.5mg Hard Capsules - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published December 2022. Accessed May 25, 2023. https://www.medicines.org.uk/emc/product/6720/smpc
  2. Highlights Of Prescribing Information, Prograf ® (Tacrolimus) Capsules PROGRAF ® (Tacrolimus) Injection, (for Intravenous Use).; Revised 2012. Accessed May 25, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
  3. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Immunosuppressants, tolerogens, and immunostimulants, 12th edition, 2011, 1008.
  4. KD Tripathi, Essentials of Medical Pharmacology, Immunosuppressant drugs, 7th edition, 2013, 881.

Safety Advice

Pregnancy: Consult your doctor Tacrotor may affect the baby; inform your doctor if you are pregnant or planning pregnancy.

Lungs: Consult your doctor Safety in lung disease is unclear; consult your doctor if you have any respiratory issues.

Breastfeeding: Unsafe Avoid using Tacrotor 0.1% Ointment while breastfeeding, as it may pass into breast milk and harm the baby.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS