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Tegafi Capsule

Salt Composition: TEGAFUR,URACIL

₹1471.00₹1838.44

Inclusive of all taxes

Tegafi Capsule

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Tegafi capsule is a combination of tegafur and uracil. It is an anti-cancer medicine that belongs to the class of medications called pyrimidine analogues. It is indicated for first-line treatment of metastatic colorectal cancer, in combination with other anti-cancer medications. Cancer is a condition in which cells multiply in an uncontrolled and abnormal manner. It is not recommended for adolescents and children. Avoid taking this medicine if you are pregnant or breastfeeding. Do not take Tegafi capsule if you are allergic to tegafur, uracil, or any other ingredients of this medicine. Inform your healthcare professional if you have liver disease, kidney disorders, or other non-cancerous conditions before starting treatment. This medicine may reduce fertility in men and women; discuss this with your doctor before starting therapy. The most common side effects are diarrhoea, nausea, vomiting, tiredness, and risk of infection.

Uses

Colorectal cancer

How it works

Tegafi capsule is a combination of two chemotherapy drugs: tegafur and uracil. tegafur is absorbed into the bloodstream, converted into the active drug 5FU in the liver, and then absorbed by tumor cells. Within the cells is an enzyme that breaks down the 5FU. The uracil slows the breakdown of 5FU, which means that the 5FU stays in the cancer cells for longer. It prevents the growth and multiplication of cancer cells and thus helps destroy the tumor.

How to Use

Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the Tegafi capsule as prescribed by your doctor. Do not open, break, crush, or chew the capsules. Swallow the capsule whole with a glass of water. Take the capsules with or without food at the same time each day.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Diarrhea Nausea, vomiting Tiredness Risk of infection Fever Bruising and bleeding Anemia Changes in skin and nail Serious Swelling in the face, and body Severe skin rashes Severe diarrhea Liver injury

Expert Tips

Do not breastfeed during the treatment with Tegafi capsule. This medicine may increase your risk of developing a blood clot. A blood clot may cause symptoms such as pain, redness and swelling in a leg, or breathlessness and chest pain. Blood clots can be very serious so it’s important to tell your doctor straight away if you notice any of these symptoms. Your doctor will perform regular blood tests during the treatment to monitor the safety and effectiveness of the therapy. Your heart and lung function will also be checked regularly. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury.

References

  1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1695-1697.
  2. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 864.
  3. Bristol-Myers Squibb (Pty) Ltd, Published on 2001; Accessed on 05/05/2023; http://www.thethaicancer.com/PDF/Drug/Drug_information/CMT/UFT.pdf

Safety Advice

Pregnancy: unsafe Tegafi capsule is unsafe for pregnant women because it may cause birth defects. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using effective contraception during the treatment.

Lungs: Consult your doctor It is unknown whether Tegafi capsule can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Tegafi capsule because the medicine passes into the breast milk in small amounts and may harm the baby. Tegafi

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS