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Tepastim 100mg Injection

Salt Composition: THIOTEPA

₹23058.00₹28120.00

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Tepastim 100mg Injection is an antineoplastic medication containing Thiotepa as its active ingredient. It is used as a conditioning regimen before stem cell transplantation and is prescribed in combination with other anti-cancer drugs for adult patients with lymph node or central nervous system cancers. Tepastim 100mg Injection serves as preparatory treatment before stem cell transplant to reduce the risk of graft rejection. It is also indicated for controlling fluid accumulation in cavities caused by cancer affecting serous membranes and for treating breast, ovarian, and bladder tumours.

Common side effects of Tepastim 100mg Injection include diarrhoea, rashes, bleeding, blood in urine, and cytomegalovirus infection. Inform your doctor if these effects persist or are concerning. Patients must notify their healthcare provider of any allergy to this medication or its components. Tepastim 100mg Injection is contraindicated in patients receiving live virus or bacterial vaccines, including the yellow fever vaccine. Patients with a history of cardiac, hepatic, renal, or pulmonary disease, or with profound myelosuppression (anaemia, neutropenia, thrombocytopenia) must inform their doctor before starting treatment. Liver and cardiac function should be monitored regularly, particularly in patients with pre-existing conditions. Tepastim 100mg Injection is not recommended for pregnant or breastfeeding women.

Dosing of Tepastim 100mg Injection is determined strictly by your oncologist based on your individual treatment plan and transplant preparation requirements. If Tepastim is unsuitable or unavailable, your physician may recommend an alternative depending on your clinical requirements.

Uses

Tepastim 100mg Injection uses are Preparation for allogeneic hematopoietic stem cell transplantation in pediatric patients with class 3 beta-thalassemia Treatment of adenocarcinoma of breast and ovary. Treatment of superficial papillary cancer of the urinary bladder.

How it works

Tepastim 100mg Injection acts by damaging the genetic material (DNA and RNA) of the cancer cells. It stops the growth and multiplication of cancer by directly attacking DNA. This causes the breakage of DNA strands. This leads to the exertion of cytotoxic effect and death of tumor cells.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Tepastim 100mg Injection side effects are Serious Severe drop in blood cell count Heart problem Kidney damage Nerve damage Lung toxicity Liver toxicity Common Cytomegalovirus infection Hemorrhage Diarrhea Blood in urine Rashes.

References

  1. ADIENNE SA, [Revised on 15th June 2020] [Accessed on 23 Nov 2022] https://pdf.hres.ca/dpd_pm/00056680.PDF
  2. Pfizer, US Food and Drug Administration, [Revised on Jan 2017] [Accessed on 23 Nov 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208264s000lbl.pdf
  3. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
  4. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.

Safety Advice

Pregnancy: Consult Your Doctor Tepastim 100mg Injection is unsafe to use during pregnancy as it may cause fetal harm. Hence, Consult your doctor for advice.

Lungs: Consult Your Doctor It is unknown whether Thioplan 15 mg Injection can be administered in lung failure patients. Please consult the doctor for more advice.

Breastfeeding: Consult Your Doctor Breastfeeding while on treatment with Tepastim 100mg Injection is not recommended. Consult your physician for advice before breastfeeding.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS