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Trelegy Ellipta Inhaler

Salt Composition: FLUTICASONE FUROATE,UMECLIDINIUM,VILANTEROL

₹2620.00₹2911.15

Inclusive of all taxes

Categories: Pulmonology

Conditions: Respiratory Disorder

Product Introduction

Trelegy Ellipta inhaler is a combination inhalation powder containing three active ingredients: fluticasone furoate, umeclidinium, and vilanterol. It is indicated for the treatment of chronic obstructive pulmonary disease (COPD) in adults, addressing symptoms including wheezing, shortness of breath, coughing, and chest tightness. The inhaler is also used to reduce exacerbation risk in patients with a history of severe respiratory symptoms associated with COPD.

Fluticasone furoate is a corticosteroid. Umeclidinium is an anticholinergic agent. Vilanterol is a long-acting beta-agonist (LABA). The three-component formulation works by relaxing and opening the airways in the lungs to improve airflow and ease breathing.

Trelegy Ellipta is administered as an inhalation powder via mouth using the inhaler device. Regular use as directed by your doctor is necessary for optimal therapeutic benefit. Do not use this medicine if you have an allergy to fluticasone furoate, umeclidinium, vilanterol, or any other ingredients in the formulation.

Before initiating treatment, inform your doctor of any existing heart, liver, or respiratory conditions. Seek immediate medical attention if you develop symptoms consistent with pneumonia or other respiratory disorders following use of this medicine.

This medicine is not recommended for patients below 18 years of age.

The most common adverse effect reported with Trelegy Ellipta inhaler is common cold. Additional adverse effects may include headache, cough, nasal congestion, oral candidiasis, and nasal infection. Notify your doctor if any adverse effects persist longer than expected or worsen in severity.

Uses

Trelegy Ellipta inhaler is approved for long-term maintenance therapy of airflow restriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. It is also indicated to reduce the worsening of COPD in patients with a history of severe breathing difficulty symptoms.

How it works

The Trelegy Ellipta inhaler contains fluticasone furoate, a corticosteroid, umeclidinium, an anticholinergic, and vilanterol, a long-acting beta(2)-agonist. Fluticasone furoate inhibits pro-inflammatory signaling molecules by activating the steroid response element and prevents lung airway inflammation brought on by exposure to antigens. Umeclidinium inhibits certain receptors in the smooth muscles of the airway, leading to the dilation of bronchi and bronchioles. Vilanterol increases certain messenger levels in our body, which causes the bronchial smooth muscles to relax.

How to Use

Your doctor will tell you how much medicine to use. Do not use more than directed. Use this medicine at the same time each day. Trelegy Ellipta inhaler is a powder that is used with its own inhaler device. Keep the medicine in the foil tray until you are ready to use the inhaler. Each time you open the cover of the inhaler and hear a click, the inhaler is ready to use. Do not close the cover until you have taken your dose. You will lose the dose if you open and close the cover without inhaling the medicine. To inhale this medicine, breathe out fully and put the mouthpiece between your lips, and close your lips firmly around it. Take one long, steady, deep breath in through your mouth. Do not breathe in through your nose. Do not block the air vent with your fingers. Remove the inhaler from your mouth and hold your breath for about 3 to 4 seconds, then breathe out slowly. When you have finished inhaling, rinse your mouth out with water. Do not swallow the water. You may clean the mouthpiece using a dry tissue, if needed, before closing the cover.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common: Cough Common cold and upper respiratory infections Sore throat Diarrhea Headache Back pain Urinary tract infections Influenza Serious: Increased heart rate Increased blood sugar levels Decreased potassium levels Hypersensitivity reaction Fungal infections Decreased bone mineral density Cataract, glaucoma Severe respiratory problems

Expert Tips

Use Trelegy Ellipta inhaler exactly as prescribed by your doctor. Follow the usage instructions correctly. Do not take more than one inhalation per day. Inform your doctor if you are pregnant, breastfeeding or if you have liver disease, heart disease, asthma, high blood pressure, heart rhythm problems, thyroid problems, or a history of eye problems. Tell your doctor right away if your condition gets worse. Your doctor may check your progress and the effects of this medicine at regular visits.

References

  1. EMA (2018). Trelegy Ellipta - European Medicines Agency . [online] European Medicines Agency. Available at: https://www.ema.europa.eu/en/medicines/human/EPAR/trelegy-ellipta#:~:text=Trelegy%20Ellipta%20is%20a%20medicine [Accessed 21 Jan. 2023].
  2. HIGHLIGHTS OF PRESCRIBING INFORMATION. (2019). [online] Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209482s003lbl.pdf [Accessed 21 Jan. 2023].
  3. reference.medscape.com. (n.d.). Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol inhaled) dosing, indications, interactions, adverse effects, and more . [online] Available at: https://reference.medscape.com/drug/trelegy-ellipta-fluticasone-furoate-umeclidinium-bromide-vilanterol-inhaled-1000165#4 [Accessed 21 Jan. 2023].
  4. medlineplus.gov. (2020). Fluticasone, Umeclidinium, and Vilanterol Oral Inhalation: MedlinePlus Drug Information . [online] Available at: https://medlineplus.gov/druginfo/meds/a618017.html [Accessed 21 Jan. 2023].
  5. www.trelegy.com. (2022). Treatment Option | TRELEGY ELLIPTA (fluticasone furoate, umeclidinium, and vilanterol) . [online] Available at: https://www.trelegy.com/ [Accessed 21 Jan. 2023].

Safety Advice

Pregnancy: Consult your doctor There is limited data regarding using Trelegy Ellipta inhaler in pregnant women to determine a drug-associated risk. If you are pregnant or think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. Do not use this medicine if you are pregnant unless your doctor tells you to take it.

Lungs: Consult your doctor Talk to your doctor before using the Trelegy Ellipta inhaler if you have liver problems.

Breastfeeding: Consult your doctor It is unknown whether Trelegy Ellipta inhaler are excreted in human milk. Ask your doctor for advice before taking this medicine. Do not use this medicine if you are breastfeeding or planning to breastfeed unless your doctor tells you to take it.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS