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Uniblastin 10mg Injection

Salt Composition: VINBLASTINE

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Uniblastin 10mg Injection

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Uniblastin 10mg Injection is an anticancer medicine that belongs to the class of mitotic inhibitors and contains the active ingredient Vinblastine. It is used in combination with other anticancer medications to treat Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, testicular cancer, breast cancer, and Kaposi’s sarcoma. Hodgkin’s and non-Hodgkin’s lymphoma are types of blood cancer that affect the lymphatic system. This injection should be administered with caution in patients who have a history of nerve damage, respiratory disorders, or gastrointestinal diseases. Inform your doctor about all the medicines you are taking, as certain drugs may interact with Vinblastine. For instance, erythromycin may increase the risk of side effects associated with this medicine. If you are receiving radiotherapy to the liver region, your doctor may postpone treatment with this injection. During therapy, your physician may regularly monitor your white blood cell count, platelet levels, blood sugar, electrolytes, and kidney function to reduce the risk of serious complications. When used together with anticancer medicines such as bleomycin or cisplatin, this medication may increase the risk of heart-related problems. Contact your doctor immediately if you notice signs of an allergic reaction, including skin rash or itching, while receiving this treatment. Since this medicine may cause birth defects, women of childbearing potential should use effective contraception throughout treatment. If you are pregnant, breastfeeding, planning to become pregnant, or think you may be pregnant, consult your doctor before using this medication. Avoid driving or operating machinery if you experience side effects that may impair your ability to do so. This injection should not be used if you are allergic to Vinblastine or any of its ingredients, have an uncontrolled bacterial infection, or if blood tests show that your white blood cell count is too low to fight infections. This medicine may affect your blood cells, so your doctor will perform regular blood tests to monitor your blood counts and evaluate your liver function. Inform your physician before starting treatment if you have liver disease, heart failure, high cholesterol, or high blood pressure.

Uses

Uniblastin 10mg injection has been indicated for treating, Hodgkin’s lymphoma Non-Hodgkin’s lymphoma Testicular cancer Breast cancer Kaposi’s sarcoma

How it works

It works by disrupting the formation of microtubules in cells. Microtubules are structures that help to support and shape cells, as well as transport molecules within cells. In cancer cells, microtubules play a key role in cell division and growth. By interfering with microtubule formation, this drug disrupts the ability of cancer cells to divide and grow, ultimately leading to their death.

How to Use

It should only be administered by a trained doctor or nurse experienced in giving chemotherapy. This medication is injected directly into a vein through a needle or catheter. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity and other factors.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Severe allergic reactions (difficulty in breathing or swallowing, swelling of hands, feet, lips, mouth, or throat, itchy rash) Swelling or pain at the site of injection (during or immediately after the injection) Common Low blood counts Convulsions Mental depression Tiredness Diarrhea Loss of appetite Nausea, vomiting Stomach cramps Hair loss

Expert Tips

This medicine can weaken the immune system, making patients more susceptible to infections. Patients should take steps to avoid contact with sick people and practise good hygiene, such as washing their hands frequently. Patients should also avoid activities that could increase their risk of injury or bleeding, such as contact sports or using sharp objects. This drug makes the skin more sensitive to sunlight, leading to sunburn, blistering, or skin discoloration. It's important to use sunscreen and protective clothing while being exposed to sunlight. It is recommended to limit your alcohol intake or avoid it altogether while taking Uniblastin 10mg injection.

References

  1. Hospira UK Limited, Electronic medicines compendium (EMC), [Revised on Sept 2020][ Accessed on 4th April 2023], https://www.medicines.org.uk/emc/files/pil.1422.pdf
  2. DBL vinblastine injection - pfizer. Available at: https://labeling.pfizer.com/ShowLabeling.aspx?id=12288 [ Accessed on 4th April 2023].
  3. Vinblastine injection -NPS MedicineWise. Available at: https://www.nps.org.au/assets/medicines/aea96da5-9c46-482b-9add-a53300ff05d1.pdf [ Accessed on 4th April 2023].
  4. HY Yap; Vinblastine given as a continuous 5-day infusion in the treatment of refractory advanced breast cancer; Cancer Treatment Reports; Published on March 1980;[ Accessed on 4th April 2023]; https://pubmed.ncbi.nlm.nih.gov/7407762/
  5. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1706.
  6. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 865.

Safety Advice

Pregnancy: unsafe Uniblastin 10mg injection is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.

Lungs: Consult your doctor It is not known whether Uniblastin 10mg injection can be administered to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Uniblastin 10mg injection because the medicine passes into the breast milk in small amounts and may harm your baby.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS