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Veltiro 100mg Injection

Salt Composition: RITUXIMAB

₹2855.00₹8156.25

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Veltiro 100mg injection contains rituximab as its active ingredient. It is used for several different disease conditions in adults. It is used alone or in combination with other medications to treat non-Hodgkin lymphoma (cancer affecting white blood cells called B-lymphocytes) and chronic lymphocytic leukaemia (the most common form of leukaemia affecting B-cells). It is also indicated to treat moderate-to-severe rheumatoid arthritis (an autoimmune condition in which the immune system attacks the body's own joint cells) in combination with methotrexate in adults. Other uses include granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels affecting primarily the lungs and kidneys) in adults and children aged 2 years and older. It is also used to treat moderate to severe pemphigus vulgaris (an autoimmune condition that causes painful blisters on the skin and mucous membranes of the mouth, throat, nose, and genitals). Veltiro 100mg injection belongs to the class of medications known as anti-CD20 monoclonal antibodies. Do not use this injection if you are allergic to rituximab or any other ingredients in this medicine, have a compromised immune system, or have any severe active infection. Inform your physician if you have heart disease, heart failure, or breathing problems before starting treatment. Discuss with your doctor if you have ever had hepatitis B infection, as the infection may reactivate in some cases and can be severe. Pregnancy and breastfeeding are not recommended during treatment with this injection. Common side effects of Veltiro 100mg injection include blood infections, reduced red blood cell count, dizziness, swelling of the face and body, itchy skin, diarrhoea, increased sweating, and low or high blood pressure. Use effective contraception during treatment and for 12 months after the last dose if you are able to become pregnant. This medicine may cause severe infusion reactions during or within 24 hours after administration. Inform your physician or healthcare professional if you experience any infusion reactions, such as elevated blood pressure, chest pain, headache, breathing difficulties, vomiting, skin rashes, or throat swelling.

Uses

Non-hodgkin’s lymphoma (NHL) Chronic lymphocytic leukemia (CLL) Rheumatoid Arthritis Granulomatosis with polyangiitis or microscopic polyangiitis Pemphigus vulgaris

How it works

Veltiro 100mg injection is a monoclonal antibody that targets the antigen CD20 expressed on the cell surface of B-lymphocytes (a type of white blood cells). When this medicine binds to the B-cell, it induces cell death in NHL and CLL. The binding action blocks cell activation and growth and cause anticancer effects. It inhibits rheumatoid factor production, antigen presentation, T-cell activation, and proinflammatory cytokine production in rheumatoid arthritis.

How to Use

It should only be administered by a trained doctor or nurse. Do not self-administer the injection. Before giving Veltiro 100mg injection, you will be given other medications (pre-medication) to reduce the possible side effects. Your doctor will decide the dose and duration of your treatment based on the disease severity and other factors. It will be given as an intravenous infusion, and you will be monitored carefully for any unwanted side effects.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Swelling in the face and body Diarrhea and nausea Itchy skin Anemia Muscle spasm Headache Urinary tract infection Fever, chills, and shivering Inflammation of nasal cavities Cough, sore throat Loss of hair Serious Increased or decreased blood pressure Chest pain Hypersensitivity reactions Hepatitis B viral infection Memory loss, trouble thinking, difficulty in walking

Expert Tips

Avoid vaccines before and during therapy. Inform your physician if you have been vaccinated recently because Veltiro 100mg injection may cause drug-induced immunosuppression. Report to your doctor immediately if you face any symptoms like chest pain, breathing difficulties, stomach pain, and skin reactions. There is limited information available on the safety of this medicine in renal failure patients; inform your physician if you have kidney disease. Vaccination with live virus vaccines is not recommended before or during the treatment for patients with rheumatoid arthritis. Inform your healthcare professional if you have any active infection during the treatment.

References

  1. HIGHLIGHTS OF PRESCRIBING INFORMATION. (2021). Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/103705s5464lbl.pdf [Accessed 9 Mar. 2023].
  2. ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS. (2020). Available at: https://www.ema.europa.eu/en/documents/product-information/mabthera-epar-product-information_en.pdf [Accessed 9 Mar. 2023].
  3. Ahmed A. Negm & Daniel E. Furst, Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout, Lange's Basic & Clinical Pharmacology, 14th Edition, 2018, 642-666

Safety Advice

Pregnancy: Veltiro 100mg injection is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for 12 months after your last dose is necessary.

Lungs: Consult your doctor It is unknown whether Veltiro 100mg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Veltiro 100mg injection because the medicine passes into the breast milk in small amounts and may harm your baby.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS