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Votrient 400mg Tablet
Salt Composition: PAZOPANIB
- Manufacturer: NOVARTIS INDIA LTD
- Pack Size: 30 TABLET(s) IN A BOTTLE
- Dosage Form: TABLET
- Strength: 400MG
- Prescription Required
- Storage: Store Votrient 400mg tablet in room temperature (25°C) Keep the injection away from the reach of children and pets. If you forgot to take a dose, take it as soon as you remember. However, skip the missed dose if it is nearly time for the next dose. Take only a partial dose to make up for a forgotten dose.
₹16108.00₹17896.00
Inclusive of all taxes
Product Introduction
Votrient 400mg tablet contains pazopanib, an antineoplastic drug belonging to the tyrosine kinase inhibitor class. It is indicated in adults for treatment of advanced renal cell carcinoma that has metastasised to other organs.
Do not take Votrient 400mg tablet if you are allergic to pazopanib or any other ingredients in this medicine. Before starting treatment, inform your doctor if you have kidney disease, cardiac problems, lung disease, liver impairment, bleeding disorders, gastric or bowel conditions, or thyroid dysfunction. This tablet may elevate blood pressure; regular monitoring during treatment is necessary. No dose adjustment is required in patients with renal disease. Your doctor will advise discontinuation of Votrient 400mg tablet at least 7 days prior to any surgical or dental procedures, as it may impair wound healing. This medicine is not recommended for patients under 18 years of age. This medicine may cause infertility; consult your doctor before commencing treatment. The most frequently reported adverse effects are diarrhoea, hypertension, hair colour changes, nausea, and vomiting.
Uses
Directly inhibits the growth and spread of cancer cells in conditions like advanced renal cell carcinoma. Helps to reduce the size and impact of tumors in conditions such as soft tissue sarcoma.
How it works
Votrient 400mg tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It interferes with the growth of blood vessels inside the cancer cells by acting against a protein called Vascular Endothelial Growth Factors (VEGF) to shrink cancer cells, ultimately stopping their growth and multiplication.
How to Use
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Do not take this medicine with food, as it affects the absorption of this medicine. Take Votrient 400mg tablet at least two hours after a meal or one hour before a meal.
Side Effects
It is crucial to monitor any adverse effects and report them to your healthcare provider for appropriate management. Common Hypertension Hair color change Increased glucose levels Decreased weight, decrease in appetite Diarrhea Nausea, vomiting Muscle and joint pain Headache Shortness of breath Tiredness Serious Heart problems Bleeding from the anus, mouth Hypothyroidism Interstitial lung disease Infections
Expert Tips
Avoid consuming grapefruit juice while undergoing treatment with this medication, as it could heighten the risk of side effects. Male patients whose partners are of childbearing potential should use effective contraception during treatment and for at least two weeks after the final dose to prevent pregnancy. It is important to take the tablet consistently at the same time each day. Your doctor will conduct regular lab tests to monitor the effectiveness of the medication.
References
- Highlights Of Prescribing Information - Pazopanib. [Revised on 2021] [cited 2023 Mar 24]. Available from: https://www.novartis.com/us-en/sites/novartis_us/files/votrient.pdf
- Summary Of Product Characteristics - Pazopanib. [revised on 2021] [cited 2023 Mar 24]. Available from: https://www.ema.europa.eu/en/documents/product-information/votrient-epar-product-information_en.pdf
- Votrient 400 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. 2021 [cited 2023 Mar 24]. Available from: https://www.medicines.org.uk/emc/product/572/smpc
- Edward Chu, Cancer Chemotherapy, Langeâs Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
Safety Advice
Pregnancy: unsafe Votrient 400mg tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for at least 2 weeks after your last dose is necessary.
Lungs: Consult your doctor It is unknown whether Votrient 400mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Votrient 400mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby.
Disclaimer
The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.