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Zeparib 100mg Tablet

Salt Composition: OLAPARIB

₹3282.00₹25312.50

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Zeparib 100mg Tablet is a PARP (poly [adenosine diphosphate-ribose] polymerase inhibitor) inhibitor containing the active ingredient Olaparib. It is indicated for the treatment of pancreatic and prostate cancer. This medication may be administered as monotherapy or in combination with other anticancer agents.

Olaparib should not be used if you have a known allergy to the active ingredient or other components of the formulation. Contact your doctor immediately if you develop breathlessness, chest pain, rapid heart rate, fever, cough, or wheezing during treatment.

Your healthcare provider will perform blood tests before initiating treatment and monthly thereafter, as this medicine may reduce red blood cell, white blood cell, and platelet counts. Inform your healthcare provider prior to starting treatment if you have a history of lung, liver, heart, or kidney disease.

This medication is not recommended during pregnancy as it may cause fetal harm and miscarriage. Women of reproductive potential should undergo pregnancy testing before beginning treatment. Continued use of contraception for at least six months after treatment completion is recommended.

Breastfeeding is not advised whilst receiving treatment, as it is unknown whether Zeparib 100mg Tablet passes into breast milk. Men should not donate sperm for at least 3 months following completion of treatment.

Inform your doctor of all medicines you are taking, including prescription medications, over-the-counter drugs, vitamins, and supplements.

Uses

Treatment of Prostate cancer Metastatic Pancreatic cancer

How it works

Zeparib 100mg Tablet works by inhibiting the enzyme poly (ADP-ribose) polymerase (PARP), which plays a role in repairing damaged DNA in cells. By inhibiting PARP, Zeparib 100mg Tablet prevents cancer cells from repairing their DNA, leading to cell death. This targeted approach is especially effective in cancers with defective DNA repair mechanisms.

How to Use

Zeparib 100mg Tablet is available as a tablet to be taken with or without food, as directed by your healthcare provider. The dose will be decided by your healthcare professional based on your conditions. Avoid crushing, opening, or dissolving the tablet and swallow it whole with a glass of water. Take the Zeparib 100mg Tablet at the same time every day.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Shortness of breath Nausea Vomiting Fatigue Dyspepsia Loss of appetite Dizziness Diarrhoea Headache Serious Neutropenia Acute myeloid leukemia Leukopenia Thrombocytopenia Lung problems

Expert Tips

Zeparib 100mg Tablet can lower blood cell counts, thus it's best to get blood tests done at regular intervals. When undergoing this therapy, stay out of direct sunlight and wear sunscreen with an SPF of at least 50 before going outside. Zeparib 100mg Tablet should not be stopped without first talking to your doctor. When using this medication, stay away from grapefruit juice as it may raise your blood levels of the drug. It is recommended to inform your doctor about other anticancer drugs you have been taking. It's critical to maintain a sufficient fluid intake because dehydration can exacerbate symptoms such as diarrhea and other gastrointestinal disorders. Even if you feel better or see a change in your symptoms, you should still talk to your doctor before stopping the Zeparib 100mg Tablet. Remember to attend all scheduled appointments and follow-up visits with your healthcare provider to ensure your treatment is effective and any side effects are managed appropriately. With proper monitoring and management, Zeparib 100mg Tablet can be an effective treatment option for certain types of cancer.

References

  1. Lynparza, United States Food and Drug Administration (USFDA), [Revised on May 2020], [Accessed on March 2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/208558s014lbl.pdf
  2. AstraZeneca UK Limited, European Medicines Compendium (emc), [Revised on August 2023], [Accessed on March 2024], https://www.medicines.org.uk/emc/files/pil.9204.pdf
  3. AstraZeneca Pharmaceuticals LP, [Revised on November 2023], [Accessed on March 2024], https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/00997c3f-5912-486f-a7db-930b4639cd51/00997c3f-5912-486f-a7db-930b4639cd51_viewable_rendition__v.pdf

Safety Advice

Pregnancy: unsafe It is not recommended to take a Zeparib 100mg Tablet during pregnancy as it may harm your unborn baby. It is necessary to inform your doctor if you are pregnant or planning to become pregnant.

Lungs: Consult your doctor Consult your doctor if you have any lung diseases before starting the treatment with Zeparib 100mg Tablet.

Breastfeeding: unsafe It is unknown whether Zeparib 100mg Tablet passes into the breast milk. It is not recommended to nurse a child during and after 1 month of completion of therapy. Please consult your doctor before breastfeeding.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS