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Zexipag 200mcg Tablet

Salt Composition: SELEXIPAG

₹741.00₹866.25

Inclusive of all taxes

Zexipag 200mcg Tablet

Categories: Cardiology

Conditions: Heart Disorder

Product Introduction

Zexipag 200mcg Tablet is a pulmonary vasodilator belonging to the class of prostacyclin receptor agonists. The active ingredient is Selexipag. It is indicated for treatment of pulmonary arterial hypertension (PAH) to improve exercise capacity and delay disease progression. Pulmonary arterial hypertension is a serious and rare condition characterised by high blood pressure in the arteries supplying the lungs, primarily affecting small blood vessels (arteries) in the lungs, leading to their narrowing and increased resistance to blood flow.

This medication is contraindicated in individuals with known hypersensitivity or allergy to Selexipag or any component of the formulation. It is also contraindicated in patients with severe coronary heart disease, unstable angina, recent myocardial infarction, decompensated cardiac failure, severe cardiac arrhythmia, or certain heart valve defects. The medication should not be used in patients who have experienced stroke within the last three months or any other cerebrovascular event that reduces blood supply to the brain. Concurrent use with gemfibrozil (a lipid-lowering agent) is contraindicated.

Patients with thyroid gland disorders should inform their physician prior to treatment initiation, as thyroid dysfunction may impact treatment considerations and the doctor will evaluate potential effects of this medication on the condition.

Zexipag 200mcg Tablet is contraindicated during pregnancy due to potential fetal harm. Breastfeeding is not recommended in patients taking this medication, as it is unknown whether Selexipag is excreted into breast milk and what effects it may have on the infant.

The drug is metabolised and excreted by the kidneys. Patients with severe renal impairment or those undergoing dialysis require dose adjustment or alternative therapy, and dosing should be determined by the treating physician.

Uses

Treatment of pulmonary arterial hypertension (PAH)

How it works

Zexipag 200mcg Tablet works by activating the prostacyclin receptors in the blood vessels of the lungs. This activation leads to the relaxation and widening of the blood vessels, reducing the elevated blood pressure in the pulmonary arteries. By dilating the blood vessels, this drug improves blood flow and reduces the workload on the heart.

How to Use

Take the Zexipag 200mcg Tablet as advised by your physician. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Headache Diarrhea Reddening of face Vomiting, nausea Pain in the jaws, muscles, legs, or joints Stuffy nose Common Weight loss Stomach pain Rashes Hyperthyroidism Reduced appetite

Expert Tips

Since this medication aims to reduce joint pain, swelling, and stiffness, it may take several weeks or months to experience the full benefits of Zexipag 200mcg Tablet, so be patient and continue taking it as doctor advice.

References

  1. Janssen-Cilag Limited, Electronic medicines compendium (EMC), [Revised on June 2022] [ Accessed on 18th July 2023], https://www.medicines.org.uk/emc/files/pil.2163.pdf
  2. Actelion Pharmaceutical US, US Food and Drug Administration, [Revised on Dec 2017] [ Accessed on 18th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207947s005lbl.pdf
  3. Olivier Sitbon et al.; Selexipag for the Treatment of Pulmonary Arterial Hypertension; The New England Journal of Medicine; Published on Dec 2015; Accessed on 18/07/2023; https://pubmed.ncbi.nlm.nih.gov/26699168/

Safety Advice

Pregnancy: unsafe Zexipag 200mcg Tablet is not recommended during pregnancy or if there is a possibility of becoming pregnant. It is advised for women to use appropriate contraceptive measures to prevent pregnancy while using this medication.

Lungs: Consult your doctor Zexipag 200mcg Tablet is safe for patients with lung problems. Consult your doctor for more advice.

Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Zexipag 200mcg Tablet because it is unknown whether the medicine passes into the breast milk and harms your baby.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS