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Zidine 300mg Tablet
Salt Composition: ZIDOVUDINE
- Manufacturer: EMCURE PHARMACEUTICALS LTD
- Pack Size: 60 TABLET(s) IN A BOTTLE
- Dosage Form: TABLET
- Strength: 300MG
- Prescription Required
- Storage: Store Zidine 300mg Tablet at room temperature (15°to 25°C). Keep the tablet out of reach of children and pets.
₹685.00₹856.17
Inclusive of all taxes
Product Introduction
Zidine 300mg tablets are an antiretroviral drug belonging to the nucleoside reverse transcriptase inhibitors (NRTI) category, containing the active ingredient Zidovudine. It is the first antiretroviral agent approved to treat HIV-1 infection. This drug may also be prescribed to prevent virus transmission from mother to fetus. Zidine 300mg tablets can cause bone marrow suppression, resulting in decreased production of red blood cells, white blood cells, and platelets, leading to anemia, thrombocytopenia (low platelet count), and neutropenia (low white blood cell count). Regular monitoring of blood cell counts is necessary, particularly during the initial stages of treatment. This medicine has been associated with mitochondrial toxicity, which may lead to serious conditions such as lactic acidosis (buildup of lactic acid in the blood) and hepatic steatosis (fatty liver). These complications are more likely to occur in patients with underlying liver disease, obesity, or a history of pancreatitis. During the early stages of HIV treatment, some patients may experience an inflammatory response to opportunistic infections. This condition, immune reconstitution syndrome, can occur after starting this drug or other antiretroviral therapies. It is important to recognise this possibility and monitor for any signs of worsening infections or inflammatory symptoms. Inform your healthcare provider if symptoms concern you or persist longer than expected. If you are allergic to this drug or its ingredients, avoid using it. Tell your physician about all medications you have been taking recently, including herbal medicines and supplements, before taking Zidine 300mg tablets.
Uses
Human Immunodeficiency Virus (HIV) Prevent transmission of the virus from mother to fetus
How it works
Zidine 300mg Tablet works by inhibiting the reverse transcriptase enzyme of HIV, restricting the replication of the viral genome, and reducing the production of new infectious viral particles. It mainly interferes with reverse transcription, and this drug helps to inhibit the spread of HIV within the body.
How to Use
It is an orally available prescription drug. Your doctor will decide the dose and duration of the drug based on the disease condition and other factors. Always take Zidine 300mg Tablet as prescribed by your doctor. Take the tablet with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Serious Liver damage Hypersensitivity reactions Myopathy Lactic acidosis Common Headache Muscle pain Nausea Anorexia Vomiting Fever Cough Anaemia Neutropenia
Expert Tips
To prevent the spread of HIV infection, avoid sharing needles or syringes, which can transmit HIV-1 infections easily. It's necessary for individuals who use injectable drugs to use sterile needles and syringes and never share them with others. Personal items should also be avoided, like toothbrushes, razor blades, or anything that can have blood or body fluids on them. They should not be shared because HIV-1 can be present in blood and certain body fluids, and sharing these items could mainly transmit the virus. Since this drug is unsafe for breastfeeding because HIV infection can be passed to the baby in the breast milk, alternative feeding methods can be followed to nourish the infant's growth. If you forget to take Zidine 300mg Tablet for the entire day, take your usual dose the next day. However, do not double-dose yourself.
References
- GlaxoSmithKline, U.S. Food & Drug Administration, [Revised on Dec 2014] [Accessed on 11th May 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019910s041lbl.pdf
- Sharon Safrin, Lange's Basic & Clinical Pharmacology, 14th Edition, 2018, Antiviral Agents, 863-894.
- KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
Safety Advice
Pregnancy: Consult your doctor Your doctor shall prescribe Zidine 300mg Tablet only if it is essential and the benefits outweigh the risks.
Lungs: Consult your doctor It is unknown whether Zidine 300mg Tablet can be prescribed for patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Breastfeeding: unsafe It is unsafe to take Zidine 300mg Tablet during breastfeeding because it tends to get excreted in human milk.
Disclaimer
The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.