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Zoleted 4mg Injection

Salt Composition: ZOLEDRONIC ACID

₹685.00₹2511.00

Inclusive of all taxes

Categories: Oncology

Conditions: Anti Cancer

Product Introduction

Zoleted 4mg contains the active ingredient Zoledronic Acid, which belongs to a class of medicines known as bisphosphonates. It is used to lower high blood calcium levels (hypercalcaemia) in adults when caused by certain types of tumours. Some cancers accelerate the normal breakdown of bone tissue, leading to an increased release of calcium into the bloodstream. This condition is referred to as tumour-induced hypercalcaemia (TIH). Zoleted 4mg is also prescribed to prevent bone-related complications in adults with multiple myeloma and bone metastases from solid tumours when used alongside standard cancer treatment.

Zoleted 4mg is also indicated for the prevention and treatment of osteoporosis in postmenopausal women and in men with weakened bones. Additionally, it is used to treat Paget's disease of bone, a disorder in which bones become enlarged, weak, painful, or more likely to fracture. It may also be prescribed to prevent or manage glucocorticoid-induced osteoporosis in men and women receiving long-term corticosteroid therapy, which can reduce bone density and increase the risk of fractures.

Do not use Zoleted 4mg if you are allergic to Zoledronic Acid, any other bisphosphonate, or any of the ingredients in this medicine. It should not be used during pregnancy or breastfeeding. Before starting treatment, inform your doctor if you have kidney or liver disease, bone disorders, or symptoms such as jaw pain, swelling, or numbness, as these conditions may require careful monitoring during treatment. This medicine is not recommended for use in children and adolescents under 18 years of age.

It is important to note that Zoleted 4mg is not a chemotherapy medicine and does not stop or slow the spread of cancer. Instead, it is used to treat bone diseases and prevent skeletal complications in patients with cancer, helping to strengthen bones and reduce the risk of fractures and other bone-related problems.

Uses

Treat hypercalcemia of malignancy Multiple myeloma Bone metastases from solid tumors Osteoporosis in postmenopausal women Osteoporosis in men Paget’s disease of bone

How it works

Zoleted 4mg primarily inhibits bone resorption. It works by slowing bone breakdown, increasing bone density (thickness), and decreasing the amount of calcium released from the bones into the blood.

How to Use

It should only be administered by a trained doctor or nurse. It will be given as a drip (infusion) into your vein. Your doctor will decide the dose and duration of the treatment based on your disease severity and other factors. Do not self-administer the medication.

Side Effects

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Nausea, vomiting Fatigue Anemia Bone pain Constipation, diarrhea dyspnea, and fever Swelling in the legs and feet Decreased weight Abdominal pain Muscle pain Tiredness Serious Changes in heart rhythm Severe hypersensitivity skin reactions Decreased calcium levels Severe bone pain Severe kidney problems Unusual fractures of the bone

Expert Tips

While being treated with zoledronic you should maintain good oral hygiene and receive routine dental check-ups. Contact your doctor or dentist immediately if you experience any problems with your mouth or teeth, such as loose teeth, pain or swelling, non-healing sores, or discharge. Inform your physician if you have kidney problems. Your doctor may advise you to take certain blood tests regularly to check the effectiveness of the therapy.

References

  1. Zoledronic acid 5 mg solution for infusion - Patient Information Leaflet (PIL) - (emc). www.medicines.org.uk. [revised on 2017] [cited 2023 Mar 28]. Available from: https://www.medicines.org.uk/emc/product/5242/pil
  2. HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use zoledronic Injection safely and effectively. See full prescribing information for zoledronic Injection. zoledronic Injection for intravenous use. [Revised on 2017] [cited 2023 Mar 28]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/203231s011lbl.pdf
  3. KD Tripathi, Hormones and Drugs Affecting Calcium Balance, Essentials of Medical Pharmacology, 8th Edition, 2019, 360-372.

Safety Advice

Pregnancy: unsafe Zoleted 4mg is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.

Lungs: Consult your doctor It is unknown whether Zoleted 4mg can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

Breastfeeding: unsafe Breastfeeding is not recommended in patients taking Zoleted 4mg because the medicine passes into the breast milk in small amounts and may harm your baby.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered as medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Self-medication can be harmful. Med For Rare does not endorse self-diagnosis or self-treatment.

Written By: Muskan Patel, M.Pharm

Reviewed By: Dr. Vishwa Patel, MBBS