CARBOPLATIN

Carboplatin is an anticancer medication approved by the U.S. FDA on 07th April 2003 for the treatment of certain types of lung and ovarian cancer. Research has demonstrated that carboplatin is effective in treating ovarian cancer and other cancers, with activity comparable to cisplatin. It exhibits a different toxicity profile, associated with reduced kidney, nerve, and ear damage compared to cisplatin. Myelosuppression represents the primary dose-limiting side effect, particularly in older patients or those with impaired kidney function.

Carboplatin is used alone or with other drugs to treat ovarian cancer . This medication helps in controlling the spread of cancer.

Carboplatin is an intravenous infusion drug that is injected through the veins. Your physician will choose the dosage and administration frequency based on your medical condition because it differs for each person.

Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them. Common side effects of carboplatin include: Loss of taste Diarrhea Constipation Hair loss Skin rashes & itchiness Kidney problems Extreme tiredness Weakness Inflammation in lung tissues Tingling or numbness in hands, arms, or legs Prickling sensation Breathing difficulties Serious side effects of carboplatin include: Decrease in the number of red blood cells (anaemia) Allergic reactions Abnormal bruising Kidney problems (haemolytic-uraemic syndrome) Hearing problems Signs of infection

Acute asthma: Do not use during a severe asthma attack; closely monitor asthma patients during treatment. Keratoconjunctivitis: Avoid using topical antibiotics for dry eye syndrome to reduce the risk of severe reactions. Paracetamol overdose: Use to treat paracetamol poisoning and monitor paracetamol levels for proper treatment. Allergic reactions: It may cause severe allergic reactions such as low blood pressure, difficulty breathing, and rash; monitor closely during IV administration. Hypersensitivity: Do not use if allergic to carboplatin or any of its components.

Carboplatin can cause heart problems, serious irregular heartbeat, heart failure, and bone marrow depression. Inform your doctor about your medical history before starting the treatment. Notify your doctor if you have a history of hypersensitivity and kidney disease. Talk with your doctor if you have recently had a yellow fever vaccination or plan to have one. This drug may cause allergic reactions. Inform your doctor if you have kidney problems and heart-based diseases. If you have any kidney condition, ask your physician to check on you more frequently

Patients of any gender may experience temporary or permanent reductions in fertility during carboplatin treatment. Discuss any fertility concerns with your doctor before starting therapy. Carboplatin may cause dizziness; do not drive or operate machinery after administration. Report any symptoms to your doctor promptly.

Wagstaff AJ, Ward A, Benfield P, Heel RC. Carboplatin. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of cancer. https://pubmed.ncbi.nlm.nih.gov/2649354/ Hospira UK Limited, Electronic medicines compendium (EMC), [Revised on Oct 2021], [Accessed on 22nd Feb 2023], https://www.medicines.org.uk/emc/files/pil.3787.pdf Teva Parenteral Medicines, Inc, U.S Food & Drug Administration FDA, [Revised on Oct 2011,[Accessed on 22nd Feb 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/077139Orig1s016lbl.pdf Wim J. F. van der Vijgh et.al; Clinical Pharmacokinetics of Carboplatin; [Published online on 09 Nov 2012];[Accessed on 22nd Feb 2023]; https://link.springer.com/article/10.2165/00003088-199121040-00002