CILOSTAZOL
Background and Date of Approval
Cilostazol received approval from the United States Food and Drug Administration (FDA) for medical use in the United States in 1999.
Uses
Cilostazol is primarily used for the management and improvement of intermittent claudication. Additionally, it is prescribed for peripheral arterial disease (PAD) to enhance blood flow and reduce the risk of thrombosis
How is it administered?
Cilostazol is administered orally in the form of tablets. It is taken orally with or without food, as directed by a healthcare professional. The recommended starting dosage and any necessary dose adjustments are determined based on the specific condition being treated and the patient's response to the medication.
Side Effects
Common side effects of Cilostazol include headache, diarrhea, abnormal stools, palpitations, and fast or irregular heartbeat. Other possible side effects may include dizziness, weakness, and increased heart rate. Some individuals may experience bleeding, including gastrointestinal bleeding or bruising. Allergic reactions, though rare, are possible and may manifest as rash, itching, swelling, dizziness, or trouble breathing.
Warnings
Cilostazol can increase the risk of bleeding. This medication may affect the cardiovascular system, potentially leading to palpitations or worsening certain heart conditions. It can lead to an allergic reaction, such as rash, itching, swelling, dizziness, or difficulty breathing.
Precautions
It is important to be cautious before taking Cilostazol if you have a bleeding disorder or are taking other blood-thinning medications.If you experience irregular heartbeat or chest pain, seek medical attention promptly. If you develop signs of an allergic reaction, such as rash, itching, swelling, dizziness, or difficulty breathing, stop taking cilostazol and seek immediate medical help.
Word of Advice
Cilostazol increases bleeding risk, requiring caution in patients with bleeding disorders or those taking concurrent anticoagulant or antiplatelet medications. Cardiac palpitations may occur; use with care in patients with existing heart conditions. Patients with hepatic or renal impairment require careful monitoring and possible dose adjustment. Prior surgery, known hypersensitivity to cilostazol or other medications, and heart failure should be disclosed to your doctor before commencing treatment. Cilostazol interacts with multiple medications; inform your healthcare provider of all current drug therapy. Older patients and those with bleeding disorders or heart failure require medical evaluation prior to initiation. Alcohol consumption requires discussion with your healthcare provider. Report any unusual symptoms to your doctor immediately whilst on this medication.
References
Mylan, Electronic medicines compendium (EMC), [Revised on 9th Mar 2020] [Accessed on 19th Oct 2023], https://www.medicines.org.uk/emc/product/2609/smpc#gref Otsuka America Pharmaceutical Inc., US Food and Drug Administration, [Revised on July 2017 ] [Accessed on 19th 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020863s024lbl.pdf
Frequently Asked Questions
How long does it take for Cilostazol to work?
Cilostazol's effects may vary from person to person. Some people may notice an improvement in their symptoms within a few weeks, while others may take longer. It is essential to follow the prescribed dosage and give it time to take effect.
What should I do if I miss a dose of Cilostazol?
If you miss a dose of Cilostazol, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
What are the common side effects of Cilostazol?
Common side effects of Cilostazol may include headache, diarrhea, abnormal stools, and palpitations. However, everyone may not experience these side effects. If you experience any unusual symptoms, contact your healthcare provider.
Can I stop taking Cilostazol if I feel better?
It is essential not to stop taking Cilostazol without consulting your healthcare provider, even if you feel better. Abruptly discontinuing the medication can lead to a return of symptoms or other health complications. Always follow your doctor's instructions regarding the duration of treatment.
Can Cilostazol be taken with food?
Cilostazol is usually taken at least half an hour before or two hours after meals. Consult your healthcare provider or read the medication guide for specific instructions on administering this medication.
What should I do if I overdose on Cilostazol?
If you suspect an overdose of Cilostazol or experience symptoms such as severe dizziness, fainting, or difficulty breathing, seek immediate medical help. Contact a poison control center or visit the nearest emergency room for assistance.