HUMAN NORMAL IMMUNOGLOBULIN
Background and Date of Approval
Human Normal Immunoglobulin is an immunomodulatory agent that was approved for medical use in 1981.
Uses
Human Normal Immunoglobulin Injection has been developed to treat adults with inflammatory disorders, primary and secondary immunodeficiencies.
How is it administered?
Human Normal Immunoglobulin is available as a vial containing solution for injection, intended for administration as an intravenous infusion. It is available in the doses 0.5g, 2.5g, 5g, 10g, and 16.5%. The dosing and frequency vary according to the medical condition and bodyweight.
Side Effects
The common side effects that are likely to occur while you are on the treatment with Human Normal Immunoglobulin Injection are headache, nausea, fever, increased heart rate, high blood pressure, chills, musculoskeletal pain, breathlessness and infusion site reactions. If you experience any allergic reactions like chest tightness, wheezing, low BP or urticaria after taking this injection, report to your doctor immediately.
Warnings
Contact your doctor immediately if you experience sudden weight gain, swelling, urticaria, chest tightness, low urine output, drowsiness, increased heart rate or breathing trouble. During the Human Normal Immunoglobulin injection treatment, your doctor may periodically monitor your blood pressure, blood sugar, electrolytes, serum osmolarity, urine output, heart, liver and kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with other autoimmune disorders, depression, seizures, blood disorders or problems in your heart, liver or kidneys. Patients with severe liver and kidney impairment should exercise caution while using this medicine. Do not use this injection if you have experienced allergic reactions to human immunoglobulin.
Precautions
t is not known if Human Normal Immunoglobulin is safe for to use during pregnancy. Tell your physician before starting this treatment if you are pregnant, think you might be pregnant or planning to have a baby. It is not known if Human Normal Immunoglobulin passes into the breastmilk. However, it is advisable to tell your physician before starting this treatment if you are a breastfeeding mother or planning to breastfeed your child.
Word of Advice
Maintain a well-balanced diet. If dizziness or fatigue occurs, avoid driving or operating machinery. Do not touch or rub the injection site after administration of this medicine. Wear loose-fitting clothing to prevent discomfort.
References
Octapharma USA Inc., US Food & Drug Administration, [Revised on Mar 2022] [Accessed on 10th Oct 2022], https://www.fda.gov/media/70911/download Octapharma AG, Therapeutic Goods Administration, [Revised on Mar 2021] [Accessed on 10th Oct 2022], https://www.tga.gov.au/sites/default/files/auspar-human-normal-immunoglobulin-210621-pi.pdf Novaretti MC, Dinardo CL, Immunoglobulin: production, mechanisms of action and formulations, Rev Bras Hematol Hemoter, 2011, 33(5), 377-82, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415776/pdf/rbhh-33-377.pdf
Frequently Asked Questions
When will you need Human Normal Immunoglobulin Injection?
Your healthcare provider will prescribe Human Normal Immunoglobulin Injection when your body does not produce sufficient antibodies on its own to defend against infections.
How to store Human Normal Immunoglobulin Injection?
Store Human Normal Immunoglobulin Injection in a refrigerator (2°C â 8°C) without freezing. Protect from light.
How long does it take for Human Normal Immunoglobulin to work?
It typically takes 30 to 60 minutes of administration for Human Normal Immunoglobulin to start working.
How do you know if Immunoglobulin therapy is working for you?
It may take up to 4 weeks of regular immunoglobulin therapy to notice a steady improvement in your symptoms. If you do not notice any changes, your healthcare provider will suggest a suitable alternative.
How is Human Normal Immunoglobulin Injection administered?
Human Normal Immunoglobulin is available as a solution for injection, intended for intravenous administration. Your healthcare provider will calculate the accurate dose and duration of this treatment based on your condition and administer this medication as an intravenous infusion.
What other precaution should you know about treatment with Human Normal Immunoglobulin?
Human Normal Immunoglobulin Injection contains maltose which may lead to falsely elevated glucose readings. If you are a diabetic, discuss with your physician and use an authentic glucometer to monitor your blood sugar levels.
What should you not take with Human Normal Immunoglobulin Injection?
Avoid receiving live vaccines for measles, mumps, rotavirus, varicella, influenza and rubella while on treatment with Human Normal Immunoglobulin Injection.