IMEGLIMIN
Background and Date of Approval
Imeglimin is an anti-diabetic drug. Imeglimin belongs to the group of medications called sodium-glucose co-transporter. FDA approved this medicine on January 8, 2014, for its medical use.
Uses
Imeglimin is available as a tablet. It treats type 2 diabetes mellitus in patients above 18 years and older.
How is it administered?
Take the Imeglimin as advised by your physician. Do not chew or break the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.
Side Effects
The common side effects of Imeglimin are nausea, vomiting, back pain, urinary tract infection, diarrhea, stomach ache, loss of appetite, dizziness, and rash. Other serious side effects are decreased vitamin b12, low blood sugar level, unusual sleepiness or tiredness, and rapid weight loss.
Warnings
This drug mainly helps to control high blood glucose (sugar) levels in individuals with type 2 diabetes. It is always taken in combination with diet and exercise. Your doctor may prescribe this medicine with other antidiabetic medications when your blood sugar is high and uncontrolled. Do not take this medicine if you are allergic to Imeglimin or any of its other ingredients. Inform your physician if you get urinary tract infections because this medicine may cause UTI. This medicine is not recommended for children and adolescents under 18.
Precautions
Your doctor will check for kidney function at least once every year or more frequently while you are taking this medicine. If you experience nausea, vomiting, fever, or cannot eat or drink while taking Imeglimin, it is important to inform your doctor. These conditions can lead to dehydration, and your doctor may advise temporarily discontinuing the medication until you have recovered. When taking this drug, diabetic ketoacidosis (DKA) can occur even if blood sugar levels are normal. If you suspect you have symptoms of DKA, it is necessary to contact your doctor or go to the nearest hospital without delay.
Word of Advice
Imeglimin can increase urination, possibly leading to dehydration if not compensated for by adequate fluid intake. Drink plenty of water often to stay well hydrated. This drug causes genital yeast infections in both males and females. Practice good hygiene, including regular washing and cleaning of the genital area, to reduce the risk of infections. Limit the intake of sugary foods, processed snacks, and high-fat meals.
References
Imeglimin, Report on the deliberation results - PMDA. [Accessed on 15th June 2023], https://www.pmda.go.jp/files/000246722.pdf Mechanism of action of Imeglimin: A novel-wiley online library. [Accessed on 15th June 2023], https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14277 Imeglimin- Uses, Interactions, Mechanism of Action | DrugBank Online. [Accessed on 15th June 2023], https://go.drugbank.com/drugs/DB12509
Frequently Asked Questions
Can Imeglimin cause weight loss?
Yes, Imeglimin can cause weight loss in some individuals. One of the effects of Imeglimin is the excretion of excess glucose in the urine. It leads to a loss of calories and can contribute to weight reduction.
How does Imeglimin work?
Imeglimin reduces glucose reabsorption and lowers the renal threshold for glucose. It works by removing excess glucose from your body via your urine and lowering the sugar in your blood.
Is Imeglimin used for type 1 diabetes?
Imeglimin is not approved for use in type 1 diabetes. It is specifically indicated for the treatment of type 2 diabetes mellitus.
Can you take Imeglimin twice a day?
Your doctor will decide the medicine's dose, strength, and frequency based on your blood sugar levels and other factors. Take Imeglimin as prescribed by your doctor
How does Imeglimin help control blood sugar levels?
Imeglimin works by inhibiting glucose reabsorption in the kidneys, increasing glucose excretion in the urine, and lowering blood sugar levels. It helps to improve glycemic control in people with type 2 diabetes.
Can Imeglimin be used in people with kidney problems?
Imeglimin should be used with caution in individuals with kidney problems. The dose adjustments can be made based on kidney function. It is important to inform your physician about any existing kidney issues or changes in kidney function before taking this drug.