IMMUNOMODULATOR
Background and Date of Approval
Immunomodulators is an immunomodulator composed of heat-killed Mycobacterium W (Mw), indicated for treatment of NSCLC (Non-small Cell Lung Cancer) and use alongside other anticancer agents to improve overall response, quality of life, and survival in patients with these conditions. It contains the active ingredient Mitomycin C, a chemotherapy drug. It may be used in combination with other chemotherapy drugs or as monotherapy. Patients should avoid live vaccines during Immunomodulators treatment or for several months after completing treatment, as immune function may be compromised. This medication can increase the risk of radiation-induced toxicity when used concurrently with radiation therapy. Dose adjustments or close monitoring may be necessary in patients receiving combined modality treatment.
Uses
Immunomodulator is an immunomodulatory agent used as adjuvant therapy in treating various types of cancer, including gastric, colorectal, and breast cancer.
How is it administered?
Immunomodulator is a medication administered intravenously (IV) by a healthcare professional. It is important to follow the healthcare provider's instructions regarding the dosage and administration of medication. Refrain from doubling the dose to make up for missed doses.
Side Effects
Immunomodulator can cause several side effects, both common and serious. Common side effects may include pain, swelling, redness at the injection site, fever, headache, fatigue, nausea, vomiting, and diarrhea. Serious side effects may include anaphylactic shock, severe hypersensitivity reactions, and pulmonary embolism.
Warnings
It is important to be aware of the warnings associated with immunomodulators. This medication can cause severe hypersensitivity reactions or anaphylactic shock in patients who are allergic to it. It is also not recommended for use in patients with autoimmune disorders or those who are immunocompromised. Other warnings include the potential for cardiac events, liver and kidney damage, and pulmonary embolism.
Precautions
Patients with a history of severe hypersensitivity reactions or anaphylactic shock should not receive Immunomodulators. It is also not recommended for use in patients with autoimmune disorders or those who are immunocompromised. Patients with a history of cardiac events, liver or kidney disease, or pulmonary embolism should be closely monitored during Immunomodulators.
Word of Advice
When prescribed immunomodulators or other medications, carefully review the warnings and precautions specific to that medicine. Patients require monitoring for allergic reaction signs including rash, itching, or swelling; seek immediate medical attention if these develop. Use with caution in patients with severe renal impairment. Pregnant and breastfeeding women should discuss potential risks and benefits with their healthcare provider before taking this medication. A healthy and balanced diet supports overall health and wellbeing.
References
Cadila Pharmaceuticals, [Revised on 2021] [Accessed on 12th Aug 2021], https://www.cadilapharma.com/research/worlds-first-innovation/ Krunal Kavathiya., et al. âDesmocollin-3 and Cancerâ. Acta Scientific Cancer Biology 3.9 (2019): 19-28, https://www.actascientific.com/ASCB/pdf/ASCB-03-0155.pdf Cancer Immunotherapy: Immune Suppression and Tumor Growth, Fourth edition, 2007, 507-536
Frequently Asked Questions
How Do Immunomodulators affect my kidney?
Immunomodulators can cause fluid retention and cardiovascular side effects such as chest pain, irregular heartbeats, and high blood pressure. Therefore, caution is advised in patients with pre-existing cardiovascular disease.
What Precautions should I take if I have taken previous chemotherapy while taking Immunomodulators?
Patients who have previously received chemotherapy may have an increased risk of experiencing adverse effects or decreased drug efficacy when receiving Immunomodulators. Therefore, caution is advised in such patients.
Can I take the vaccine while taking Immunomodulators?
It is generally safe to receive vaccines while taking Immunomodulators, but you should consult your healthcare provider to determine the best approach for your situation. It can affect the body's immune system and may impact certain vaccines' effectiveness.
What is the difference between Immunomodulators and other cancer treatments?
Immunomodulators is an immunomodulatory therapy that stimulates the immune system to recognize and attack cancer cells. Other cancer treatments, such as chemotherapy and radiation therapy, kill cancer cells directly.