MEGESTROL
Background and Date of Approval
Megestrol is an anticancer, antianorexia and anticachectic medication that received approval for medical use in September 1993.
Uses
Megestrol Tablet has been developed to treat hormone-dependent cancer like endometrial and breast cancer. Its off-label indications include treatment of cancer-related loss of appetite (anorexia) and muscle loss (cachexia).
How is it administered?
Megestrol is available as a tablet in doses 40mg and 160mg. The initial dose is 40mg four times a day and the maximum dosage is 800mg. The dosage and frequency vary according to the type of cancer.
Side Effects
The common side effects that are likely to occur while you are on the treatment with Megestrol Tablet are weight gain, high blood sugar, constipation, diarrhea, impotence, rashes, flatulence, asthenia, pain and changes in urine frequency. Call your healthcare provider if you experience allergic reactions, high blood pressure, chest pain, hot flashes, mood swings or any other discomfort after taking this medicine.
Warnings
Megestrol Tablet is not recommended for those who are hypersensitive to Megestrol or its ingredients. Tell your doctor if you still get your periods. During the Megestrol Tablet treatment, your doctor may periodically monitor your blood sugar levels and check for the presence of adrenal suppression to prevent serious complications. Report to your doctor if you have HIV, endocrine disease, psychiatric disorders, thrombophlebitis, heart problem, liver disease or kidney problem.
Precautions
Megestrol Tablet may cause fertility problems in men and women. This Tablet is not recommended for pregnant women due to its ability to cause fetal harm and miscarriage. Inform your healthcare provider before starting this treatment if you are pregnant or planning to have a baby. Pregnancy testing is recommended for women of reproductive potential before starting Megestrol treatment. Discuss effective contraceptive methods to use during treatment with Megestrol and notify your healthcare provider right away if you get pregnant during this treatment. Do not breastfeed during treatment as Megestrol can pass into the breastmilk and cause potential harm to the baby.
Word of Advice
If you experience tiredness or weakness, avoid driving or operating machinery. Inform your doctor before taking megestrol if you are currently taking any prescription medications, over-the-counter medicines, or supplements.
References
1. AA Pharma Inc., [Revised on Sep 2021] [Accessed on 1st Oct 2022], https://www.aapharma.ca/downloads/en/PIL/2021/Megestrol_PM_EN.pdf 2. Chris Manikkuttiyil; Hoang Nguyen, Megestrol, StatPearls [Internet], [Revised on Jul 2022] [Accessed on 1st Oct 2022], https://www.ncbi.nlm.nih.gov/books/NBK559205/#:~:text=Megestrol%20is%20a%20synthetic%20form,the%20progesterone%20receptor%20than%20progesterone .
Frequently Asked Questions
How long does it take for Megestrol to show effects?
It typically takes 1 to 3 hours after the first dose for Megestrol to attain peak concentration in the blood and the result can be seen in 3 to 4 weeks
Is it safe for men and women of reproductive age to use Megestrol Tablet?
Megestrol Tablet may cause fertility problems in men and women. This Tablet is not recommended for pregnant women due to its ability to cause fetal harm and miscarriage. Inform your healthcare provider before starting this treatment if you are pregnant or planning to have a baby.
Can you drink or smoke while on treatment with Megestrol?
Drinking alcohol and smoking cigarettes can increase the possibility of side effects and reduce the efficacy of Megestrol. Hence, it is not recommended to drink or smoke while on this treatment.
Who should not take Megestrol Tablet?
Patients who are allergic to Megestrol or its ingredients should not take Megestrol Tablet. This medicine is not intended for pregnant women.
How long can you take Megestrol?
You can take Megestrol Tablet 4 times a day for up to 2 months to notice visible results.
Does Megestrol cause blood clots?
Treatment with Megestrol can result in the formation of blood clots in the legs and lungs.
How to store Megestrol Tablet?
Store Megestrol Tablet at a temperature below 25°C and protect from light and moisture.