SELEGILINE

The US FDA approved selegiline on 27 February 2006 for the treatment of Parkinson's disease.

Selegiline is used in the treatment of Parkinson’s disease. This medicine can be used by itself initially to manage your condition. Later on, it can also be used with other medications, like Levodopa, to help with specific symptoms that might come and go as your condition changes.

Take the Selegiline as your physician advises. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.

Some Serious side effects while taking Selegiline are abnormal liver functions, confusion, experiencing unreal situations, and depression, while common side effects encompass sore mouth, swollen gums, loss of balance, slow heartbeat, dizziness, headache, shaking, sleep disorders, fluctuations in blood pressure, blocked nose, sore throat, back pain, joint pain, muscle cramps, tiredness, ear disorders, excessive sweating, constipation, and diarrhea.

Do not use Selegiline if you are allergic to Selegiline or any of its ingredients. Do not take antidepressants, opioid painkillers, MAO inhibitors, migraine medications, or sympathomimetic drugs. Avoid taking this medicine if you have stomach ulcers or a non-Parkinson's related movement disorder. Stop antidepressants weeks before starting this medicine, and consult your doctor for guidance. Avoid taking this medicine with Levodopa if you have any of the following conditions: significant heart or blood vessel problems, chest pain, high blood pressure, irregular or fast heartbeat, overactive thyroid gland, narrow-angle glaucoma, adrenal gland tumor, prostate tumor, or severe mental health issues like schizophrenia or advanced dementia.

Before taking Selegiline, consult your doctor or pharmacist if any have uncontrolled high blood pressure, chest pain, palpitations, or abnormal heartbeat, kidney or liver issues, treatment for mental illness, anxiety, or sleep problems, a history of stomach ulcers, concurrent use of Levodopa (which may require dose adjustments and close monitoring), upcoming surgery (Eldepryl may interact with anesthesia medications), or a history of unusual urges or behaviors like excessive gambling or sexual behavior. Before taking the medicine, notify your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or are breastfeeding.

Adhere to your doctor's guidance throughout treatment. Report any concerning symptoms or adverse effects to your healthcare provider without delay. Do not discontinue selegiline unless directed by your doctor. Avoid breastfeeding while taking selegiline tablets. Your doctor will advise if dose adjustment is necessary. Consult your doctor for additional information regarding your treatment.

Orion Pharma (UK) Limited, Electronic Medicines Compendium (EMC), [Revised on Mar 2021] [Accessed on 21st Aug 2021], https://www.medicines.org.uk/emc/files/pil.2251.pdf AA Pharma Inc., [Revised on 19th Mar 2021] [Accessed on 21st Aug 2021], https://www.aapharma.ca/downloads/en//PIL/2021/SelegilinePM_ENG.pdf KD Tripathi, Antiparkinsonian Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 452-461. Michael J. Aminoff, Pharmacologic Management of Parkinsonism & Other Movement Disorders, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 492-510.