ALPHA KETOANALOGUE
Background and Date of Approval
Alpha Ketoanalogue is a nutritional supplement indicated for improvement of nutritional status in patients with chronic kidney disease.
Uses
Alpha Ketoanalogue has been developed to prevent and treat kidney damage in patients with chronic kidney disease with glomerular filtration rate less than 25 ml per minute. It corrects faulty protein metabolism due to low protein intake (less than 40g/day). It delays the disease progression and the onset of dialysis treatment by preserving the nutritional status.
How is it administered?
Alpha ketoanalogue is available in the form of powder, granules and tablets. The dose and frequency vary according to body weight and glomerular filtration rate.
Side Effects
Alpha Ketoanalogue is not associated with any serious side effects, however, hypercalcemia is the most common side effect. Your healthcare provider will regularly monitor your serum calcium levels to check for hypercalcemia and would suggest reducing the intake of calcium and vitamin D sources.
Warnings
During the Alpha Ketoanalogue treatment, your doctor may periodically monitor your serum calcium, serum phosphate and other kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with hereditary phenylketonuria.
Precautions
There is no sufficient information about the impact of Alpha ketoanalogue in pregnant and breastfeeding women. Exercise caution before using Alpha ketoanalogue during pregnancy and breastfeeding.
Word of Advice
Maintain a calorie-rich diet. Use Alpha Ketoanalogue only as recommended by your healthcare provider.
References
Centor Pharma, [Revised on Jan 2021] [Accessed on 0th Aug 2022], https://www.centorpharma.com/downloads/2021/nephrology/NEFROGARD.pdf Wu C-H, Yang Y-W, Hung S-C, Kuo K-L, Wu K-D, Wu V-C, et al., (2017) Ketoanalogues supplementation decreases dialysis and mortality risk in patients with anemic advanced chronic kidney disease, PLoS ONE, 12(5): e0176847, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419544/pdf/pone.0176847.pdf Hospimax, [Accessed on 30th Aug 2022], http://www.hospimax.com/formulation/Pospondyl%20website%20data.pdf La Renon Healthcare Pvt Ltd., [Revised on 2019] [Accessed on 30th Aug 2022], https://www.larenon.com/wp-content/uploads/2019/03/IMPULOG.pdf
Frequently Asked Questions
What is Alpha Ketoanalogue used for?
Alpha Ketoanalogue is a nutritional supplement indicated to improve kidney health in patients diagnosed with chronic kidney disease by decreasing uremic toxins, reducing proteinuria, delaying the onset of dialysis treatment and improving metabolism.
Is it safe to use Alpha Ketoanalogue during pregnancy?
While for women with reproductive potential subjected to Alpha Ketoanalogue , it is advised to discuss with your doctor regarding the effective birth control methods during the treatment. Also, to be continued for a minimum of 6 months after the treatment course completion as this medicine may impair fertility.
Who should not use Alpha ketoanalogue?
People who are hypersensitive to Alpha ketoanalogue or any of its excipients, those with high calcium levels in their blood and disturbed amino acid metabolism should not use Alpha ketoanalogue.
What should you not take with Alpha ketoanalogue?
Avoid taking medicines like tetracycline, ciprofloxacin, norfloxacin, estramustine and medications containing iron and fluoride while on treatment with Alpha ketoanalogue.
How do you manage hypercalcemia due to Alpha ketoanalogue treatment?
Your physician will regularly monitor pure serum calcium levels and if there is a suspicion of hypercalcemia, you will be required to reduce the intake of calcium containing foods and Vitamin D.
How do you store Alpha Ketoanalogue?
Store Alpha Ketoanalogue at room temperature, away from the reach of children.