DAPOXETINE

Dapoxetine is classified pharmacologically as a selective serotonin reuptake inhibitor (SSRI).

Dapoxetine is used primarily for the treatment of premature ejaculation in adult men. As a selective serotonin reuptake inhibitor (SSRI), it helps increase serotonin levels in the brain, which in turn delays ejaculation and improves ejaculatory control. It is typically prescribed as an on-demand treatment, taken one to three hours before anticipated sexual activity. The main and approved use of this medication is for managing premature ejaculation, allowing men to have more satisfying and prolonged sexual experiences.

Dapoxetine is typically administered orally in the form of tablets or capsules. The medication is taken by mouth with water and is commonly used as an on-demand treatment for premature ejaculation. It is essential to follow the guidance provided by a healthcare professional for safe and effective use.

Common side effects of Dapoxetine may include nausea, headache, dizziness, diarrhea, fatigue, and dry mouth. These side effects are usually mild and temporary; most individuals tolerate the medication well. However, there are more serious or less common side effects that may require immediate medical attention, such as allergic reactions (e.g., skin rash, itching, swelling), fainting or loss of consciousness, severe dizziness or lightheadedness, changes in mood or behavior (e.g., agitation, anxiety), and vision changes or blurred vision.

Dapoxetine has been associated with an increased risk of suicidal thoughts, especially in individuals under 25. This medication may increase serotonin levels, and in combination with other medications affecting serotonin (such as antidepressants), it may lead to serotonin syndrome, a potentially life-threatening condition. It may cause a drop in blood pressure, leading to orthostatic hypotension, especially when changing positions (e.g., from lying down to standing up). It may lower the seizure threshold in some cases.It has been associated with a slight increase in bleeding time.

Close monitoring for changes in mood, behavior, or suicidal ideation is crucial during treatment with this medication. Avoid concurrent use of this medication with other serotonergic drugs. Take precautions to prevent falls and dizziness. Stay adequately hydrated while using it, especially if experiencing diarrhea or vomiting, to avoid dehydration. Do not exceed the recommended dosage of this medication to avoid an increased risk of side effects or potential overdose.

Inform your healthcare provider of any history of allergic reactions or medication hypersensitivity before beginning Dapoxetine. Do not exceed the recommended dosage to avoid increased risk of side effects or potential overdose. Exercise caution if you have low blood pressure or a tendency to faint, as Dapoxetine may cause a decrease in blood pressure or dizziness. Should you experience symptoms of dehydration such as diarrhea or vomiting, ensure adequate hydration. Avoid sudden changes in posture to prevent orthostatic hypotension. Disclose any history of bleeding disorders or concurrent use of blood-thinning medications, as Dapoxetine has been associated with a slight increase in bleeding time. Dapoxetine is typically used as an on-demand medication for premature ejaculation; follow your healthcare provider's guidance regarding appropriate duration of treatment.

KD Tripathi, Essentials of Medical Pharmacology, Antidepressant and antianxiety drugs, 7th edition, 2013, 461 - 462. A. Menarini Farmaceutica Internazionale SRL, Electronic medicines compendium (EMC), [Revised on 28 Sep 2021] [Accessed on 3rd August 2023], Priligy 30 mg film-coated tablets - Summary of Product Characteristics (SmPC) Chris G McMahon; Dapoxetine: a new option in the medical management of premature ejaculation; Therapeutic Advances in Urology; Published on Oct 2012; Accessed on 29/06/2021; https://www.ncbi.nlm.nih.gov/pubmed/23024705