IBANDRONIC ACID
Background and Date of Approval
The U.S. FDA approved Ibandronic Acid, an anti-resorptive medication, for the treatment of osteoporosis and hypercalcaemia on 16 May 2003.
Uses
Ibandronic Acid has been developed to treat osteoporosis and prevent bone complications in patients diagnosed with bone cancer. A condition called tumor-induced hypercalcemia is common among people diagnosed with cancer. Ibandronic acid reduces blood calcium levels in such conditions.
How is it administered?
Ibandronic Acid Injection Ibandronic Acid is available as a single-dose vial for injection in the dose 6mg and as tablets in the doses 50mg and 150mg. The injection is intended for administration as an intravenous infusion after reconstitution every 4 weeks. Your healthcare provider will prescribe an accurate dose depending on your health condition. If you have been diagnosed with a kidney problem, your doctor will administer a lower dose. Ibandronic Acid Tablet Ibandronic acid tablet is usually taken once a month with a glass of water. Avoid chewing, breaking, or crushing it. Do not lie down immediately after taking this medicine. If this medicine is prescribed, your physician will choose the dosage based on your medical condition because it differs for each person.
Side Effects
The common side effects that are likely to occur while you are on the treatment with Ibandronic Acid are low levels of calcium, headache, flu, tiredness, weakness, flatulence, chills, muscle pain, nausea, vomiting, back pain and diarrhea. If you experience any reactions like rashes, bruising, swelling, and itching at the Injection site, report to your doctor immediately.
Warnings
During the Ibandronic Acid Injection treatment, your doctor may periodically monitor your blood calcium, phosphorus and magnesium and kidney parameters to prevent serious complications. Get a dental appointment before starting treatment with Ibandronic Acid Injection. Tell your healthcare provider before starting treatment with Ibandronic Acid Injection if you have been diagnosed with hypocalcemia, a problem in your heart or kidneys, or you are undergoing chemotherapy/radiotherapy. Get immediate medical attention if you have dizziness, severe nausea/vomiting, breathlessness or severe stomach ache.
Precautions
Ibandronic Acid Injection is not recommended for use during pregnancy and breastfeeding. Tell your healthcare provider before starting this treatment if you are pregnant, think you might be pregnant, breastfeeding, or planning to have a baby.
Word of Advice
Ibandronic Acid Injection may cause dizziness and nausea in some patients. If you experience discomfort during treatment, refrain from driving or operating machinery. Ensure adequate water intake before treatment to reduce the risk of dehydration.
References
KD Tripathi, Hormones and Drugs Affecting Calcium Balance, Essentials of Medical Pharmacology, 8th Edition, 2019, 360-372. Apotex Inc., [Revised on Feb 2017] [Accessed on 12th Oct 2022], https://www.apotex.com/products/us/downloads/pre/iban_imtb_ins.pdf Atnahs Pharma Australia Pty Ltd., [Revised on Oct 2018] [Accessed on 12th Oct 2022], https://secure.guildlink.com.au/gc/ws/iy/pi.cfm?product=iypbondr
Frequently Asked Questions
Who should not use Ibandronic Acid Injection?
Ibandronic Acid Injection is not recommended for people who cannot sit for more than 30 minutes, patients with digestive issues and patients who are hypersensitive to Ibandronic Acid, bisphosphonates, or its excipients.
What should you keep in mind while taking Ibandronic acid tablet?
Do not lay down within 60 minutes of taking the tablet. Sitting upright after taking Ibandronic acid Tablet helps prevent oesophageal irritation. Do not chew Ibandronic acid tablets as it might lead to mouth ulcers.
How to manage the side effects of Ibandronic acid?
Pay close attention to your symptoms during treatment with Ibandronic acid and report to your healthcare provider if you experience any unusual symptoms. Maintain proper oral and dental hygiene during this treatment.
How long do the side effects of Ibandronic acid last?
Side effects of Ibandronic acid last for up to 24 to 48 hours after the first dose.
Can you take a Vitamin D tablet with Ibandronic acid?
Wait for an hour after taking Ibandronic acid, before you take any other medications or supplements.
How long should you take Ibandronic acid?
You should take Ibandronic acid for at least six months to notice maximum effects. You can take this medicine for as long as it works for you.