MACITENTAN
Background and Date of Approval
The U.S. FDA approved macitentan on 18 October 2013. It is indicated for long-term treatment of pulmonary arterial hypertension (elevated blood pressure in the pulmonary arteries) in adults.
Uses
It is used to treat long-term treatment of pulmonary arterial hypertension (high blood pressure in the arteries) in adults. It can be used alone or along with other medicines for PAH.
How is it administered?
Take macitentan tablets are available as 10mg tablets which can be consumed orally. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.
Side Effects
The common side effects that are experienced while you are on the treatment with macitentan are anaemia, headache, bronchitis, nasopharyngitis, oedema, pharyngitis, urinary tract infection, hypotension, nasal congestion, and flushing.
Warnings
Consult your doctor if you are allergic to macitentan or have a liver or lung disorder. Consult your doctor if you are planning to get pregnant or think you may be pregnant or while breastfeeding, and it may cause infertility in males.
Precautions
The safety and effectiveness of the drug have not been established in children , hence it is not recommended in children. Speak with your doctor about your medical history to the doctor before taking this medicine.
Word of Advice
Your doctor may monitor your liver function and blood level, as this medicine may reduce red blood cells and alter liver enzymes. Patients with lactose intolerance or soy allergy should inform their doctor before taking this medicine. Patients with kidney disease should exercise caution and inform their doctor before taking this medicine, as it may cause a reduction in blood pressure and haemoglobin levels. Inform your doctor if you are allergic to black pepper (piperine).
References
Janssen Pharmaceutica NV., Electronics Medicines Compendium (EMC), [Revised on Jan 2023], [ Accessed on 18 Oct 2023], https://www.medicines.org.uk/emc/files/pil.5223.pdf Actelion Pharmaceuticals US, Inc., Food and Drug administration, [Revised on Oct 2018], [Accessed on Oct 18 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/204410s017lbl.pdf KD Tripathi, Essentials of Medical Pharmacology, Androgens and drugs for erectile dysfunction, 7th edition, 2013, 296-300.
Frequently Asked Questions
What are the precautions I need to take while taking macitentan?
Inform your medical history to the doctor. It will be useful for him to treat you based on your health. Inform your doctor if you have kidney, liver, or lung disease before starting using the medicine.
What are things I should be cautious about macitentan?
Individuals who have lactose intolerance or are allergic to soy should inform their doctor before taking the medicine.
What happens if a pregnant woman takes macitentan?
It is not recommended for pregnant women, as it may cause undesirable effects if used during the period of pregnancy.
Is there a specific monitoring schedule or tests I must undergo while taking macitentan?
You may be advised to monitor your liver function and blood level, as this medicine may reduce red blood cells and alter the liver enzyme.
Can I drive while taking a macitentan?
It may cause headaches, tiredness, or drowsiness, which alters your driving ability. So, it is advised to consult your doctor before handling heavy machines or vehicles.