STREPTOKINASE
Background and Date of Approval
Streptokinase is classified as a fibrinolytic agent used to dissolve blood clots.
Uses
Streptokinase is used in the treatment of several medical conditions. It is a thrombolytic agent to dissolve blood clots and restore healthy blood flow. Primarily, it is utilized for acute myocardial infarction (heart attack) to reopen blocked coronary arteries, deep vein thrombosis, and pulmonary embolism to address thrombosis in dialysis fistulas or grafts.
How is it administered?
Streptokinase is administered through the intravenous (IV) route. It may also be delivered through an arterial catheter for more localized treatment. Healthcare professionals perform administration following prescribed dosages and guidelines.
Side Effects
Common side effects include bleeding or bruising at the injection site, fever, and skin reactions like rash. More serious side effects can occur, such as significant bleeding, allergic reactions with symptoms like swelling or difficulty breathing, and a sudden drop in blood pressure.
Warnings
Streptokinase increases the risk of bleeding. Serious allergic reactions such as rash, itching, swelling, and breathing difficulties are rare but possible. This medication can lead to a sudden drop in blood pressure. Some medications can interact with this medication and impact its safety and effectiveness.
Precautions
Use Streptokinase cautiously in individuals with bleeding disorders, recent surgeries, ulcers, or other conditions that heighten bleeding risk. Watch for signs of allergic symptoms such as rash, itching, swelling, and breathing difficulties. Seek immediate medical attention if any allergic reactions occur. Monitor blood pressure during the administration of this medication..Inform your healthcare provider about all medications you are taking.
Word of Advice
Monitor for signs of allergic reactions, including rash, itching, swelling, and difficulty breathing. Discontinue Streptokinase immediately and seek medical attention if any allergic symptoms develop. Exercise caution in patients with a history of bleeding disorders, recent surgery, ulcers, or other conditions that increase bleeding risk. Monitor blood pressure during administration and manage any hypotensive episodes. Follow the dosage prescribed by your doctor. Patients with severe liver or kidney impairment require assessment by their healthcare provider to determine appropriate use. Use Streptokinase with caution in patients who have recently undergone surgery or sustained significant trauma.
References
KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting Coagulation, bleeding and thrombosis, 7th edition, 2013, 626. Tetris Pharma Ltd, Electronic medicines compendium (emc), [Revised on 18th Dec 2021] [Accessed on 25th 2023], https://www.medicines.org.uk/emc/product/13114/smpc#gref Adinarayana Kunamneni, Thaer Taleb Abed Abdelghani, Poluri Ellaiah; Streptokinase--the drug of choice for thrombolytic therapy; Journal of Thrombosis and Thrombolysis; Published on Feb 2007; Accessed on 25/08/2023; https://pubmed.ncbi.nlm.nih.gov/17111203/
Frequently Asked Questions
Is Streptokinase still commonly used today?
Due to newer and safer thrombolytic agents available, Streptokinase's usage has decreased over the years. Healthcare providers often opt for these alternatives.
What should I do if I miss a dose of Streptokinase?
Streptokinase is usually administered by healthcare professionals in controlled settings, so missing a dose isn't applicable in the same way as oral medications. Follow your healthcare provider's instructions.
How long does a Streptokinase infusion typically take?
The duration of an infusion can vary based on the condition being treated and the patient's response. Healthcare providers determine the appropriate duration.
Can Streptokinase dissolve all types of blood clots?
Streptokinase is effective for certain clots, but its use is limited to specific conditions. Healthcare providers choose treatments based on clot location and characteristics.
Can Streptokinase be used in emergencies?
Yes, Streptokinase might be considered to restore blood flow quickly in emergencies like heart attacks and pulmonary embolisms. However, alternatives are often preferred.
What should I do if I experience any adverse effects while on Streptokinase?
Contact your healthcare provider or seek medical attention immediately if you experience any unexpected or concerning side effects.