TADALAFIL

Tadalafil is the active ingredient in this medication. The U.S. Food and Drug Administration (FDA) approved it on November 21, 2003, initially for the treatment of erectile dysfunction. Subsequently, the FDA granted additional approvals for use in pulmonary arterial hypertension and benign prostatic hyperplasia (BPH).

Tadalafil treats Erectile dysfunction and benign prostate hyperplasia (BPH).

Tadalafil can be consumed orally as advised by the doctor. The capsules are typically taken with water, with or without food, following the prescribed dosage and frequency for oral consumption. It is usually taken as needed, approximately 30 minutes to 1 hour before sexual activity. The available doses are 5mg, 10mg and 20mg.

Tadalafil can cause both common and serious side effects. Common side effects include headache, indigestion, back pain, muscle aches, flushing, and nasal congestion. Serious side effects are rare but may include allergic reactions, chest pain, irregular heartbeat, sudden vision loss or changes, priapism (prolonged and painful erection), and hearing loss or changes in hearing.

It is not recommended to take tadalafil if you are allergic to the active compound tadalafil and its constituents. This medication is not advised to be used in women and individuals under 18. Tadalafil carries several important warnings that should be considered. These include the risk of priapism, a prolonged and painful erection requiring immediate medical attention. It can also cause drops in blood pressure, and individuals with pre-existing cardiovascular conditions should use caution. Rare sudden vision or hearing loss cases have been reported, and allergic reactions may occur.

Tadalafil should be used with care in individuals with liver or kidney impairment, and caution is advised when consuming alcohol or grapefruit juice. Other considerations include the potential for interactions with certain medications and the need to disclose relevant medical conditions. Coadministration with riociguat may produce potentially fatal episodes of syncope or symptomatic hypotension. It should not be administered with organic nitrates as it may raise hypotension. Inform your physician about any serious heart disorders, low or high blood pressure, vision problems, sickle cell anemia, liver disorders, kidney disorders and if you had a recent heart attack.

Tadalafil requires careful consideration before use. Inform your healthcare provider of any pre-existing medical conditions, particularly cardiovascular disease, liver or kidney impairment, anatomical deformities of the penis, or prior history of priapism. Exercise caution if you have bleeding disorders, stomach ulcers, or retinitis pigmentosa, a condition characterised by progressive pigmentation of the retina. The medication may interact with nitrates and alpha-blockers. Limit alcohol consumption and avoid grapefruit juice, as both can alter medication metabolism and reduce efficacy. Tadalafil is contraindicated in women and in patients below 18 years of age. Seek immediate medical attention if priapism develops—an erection persisting longer than four hours—as this may result in permanent penile damage.

Eli Lilly Canada Inc, [Revised on 28th May 2020], [Accessed on 12th March 2024], https://pi.lilly.com/ca/cialis-ca-pm.pdf Lilly USA, LLC, US Food and Drug Administration, [Revised on Oct 2011] [ Accessed on 12th March 2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021368s20s21lbl.pdf KD Tripathi, Essentials of Medical Pharmacology, Androgens and drugs for erectile dysfunction, 7th edition, 2013, 303-304.