AMLODIPINE
Background and Date of Approval
The U.S. FDA approved Amlodipine for hypertension (high blood pressure) and a rare form of angina (prinzmetal or variant angina) on 14 June 1996. Amlodipine is an antianginal agent containing the active ingredient amlodipine, which belongs to the medication class of calcium channel blockers.
Uses
Amlodipine is used to treat hypertension (high blood pressure) and a rare form of angina (prinzmetal or variant). In hypertension conditions, this medicine relaxes the blood vessels and makes the blood pass smoothly. In angina, it improves the blood supply, which prevents chest pain.
How is it administered?
Take the Amlodipine tablet as your physician advises. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.
Side Effects
The most common side effects of Amlodipine are odeama (build-up of fluid), headache, dizziness, changes in bowel activity (diarrhea, constipation, indigestion ), eye disturbance, double vision, weakness irregular heartbeat. Serious side effects while taking Amlodipine are instant wheeziness, chest pain, shortness or difficulty breathing, swelling in eyelids, face, lips, throat, or tongue, skin problems (rashes, mucous membrane inflammation, Johnson syndrome, toxic epidermal necrolysis), heart attack, abnormal heat beat pancreas inflammation.
Warnings
Inform your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or breastfeeding. Kidney patients should take Amlodipine cautiously and inform their doctor about all the underlying medical conditions. Also, in such cases, dose adjustment will be advised. Notify your doctor if you are consuming antibiotics or anticoagulants (blood clots). Suppose you experience encephalopathy (A condition characterized by impaired brain function).
Precautions
Inform your doctor if you are older or need any dose adjustments. Notify your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or breastfeeding. This medicine should be only used for hypertension conditions in adolescents and children from 6 - 17 years of age. Do not consume grapefruit juice or grapefruit while taking this tablet. It is not suggested to use this medicine under the age of 6 years because it has yet to be studied.
Word of Advice
Patients with liver or heart conditions should use Amlodipine with caution and inform their doctor of all underlying medical conditions. Do not discontinue the medicine without medical advice. Do not take a double dose to compensate for a missed dose. Inform your doctor if you experience any serious side effects. Your doctor will advise if dose adjustments are necessary. Contact your doctor for further information. Avoid consumption of grapefruit or grapefruit juice. Keep out of sight and reach of children and pets. Do not freeze the medicine. Store below 25°C. Always verify the expiry date before use.
References
Dr. Reddyâs Laboratories (UK) Ltd., Electronic medicines compendium (emc), [Revised on September 2022] [ Accessed on 29th May 2023], Version 1 (medicines.org.uk) Pfizer labs, US Food and Drug Administration, [ Accessed on 29th May 2023], Norvasc (amlodipine besylate) tablets label (fda.gov)
Frequently Asked Questions
How can I cope with the side effects of Amlodipine?
Stay hydrated by drinking plenty of fluids if you experience any side effects while taking Amlodipine. Your medical professional may also recommend over-the-counter or prescription medications to help manage your side effects.
Can I dissolve the Amlodipine and drink it instead of swallowing it?
No, you should not dissolve the tablet and drink the solution. This medicine was designed to be swallowed whole with water. It's mandatory to follow the instructions provided by your healthcare provider to avoid the side effects of Amlodipine.
Can I use an Amlodipine for children?
Amlodipine should not be used in children under six years of age.
Are there any serious side effects of Amlodipine I should be aware of?
Yes, side effects of Amlodipine may include severe allergic reactions and liver or kidney problems. It is mandatory to seek medical attention if you encounter any side effects, such as difficulty breathing, swelling, nausea, and rashes.
Is Amlodipine considered a safe medication?
Amlodipine is generally safe when prescribed by a healthcare professional. However, you must consult your doctor, provide your complete medical history, and disclose any other medications you take.